N-(3-aminopropyl)pentylamine | 58823-15-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(3-aminopropyl)pentylamine
• 英文别名: N-pentyl-propanediyldiamine；N-Pentyl-propandiyldiamin；N1-pentylpropane-1,3-diamine；N'-pentylpropane-1,3-diamine
• CAS: 58823-15-7
• 化学式: C₈H₂₀N₂
• 分子量: 144.26
• InChiKey: BDSOOXUHZWICIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(3-aminopropyl)pentylamine 、 6,9-二氯-2-甲氧基吖啶 在 苯酚 作用下， 生成 N-(6-chloro-2-methoxy-acridin-9-yl)-N'-pentyl-propanediyldiamine
  参考文献：
  名称：

  Burckhalter et al., Journal of the American Chemical Society, 1943, vol. 65, p. 2013

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(戊氨基)丙腈 在 乙醇 、 镍 作用下， 70.0 ℃ 、392.24 kPa 条件下， 生成 N-(3-aminopropyl)pentylamine
  参考文献：
  名称：

  Burckhalter et al., Journal of the American Chemical Society, 1943, vol. 65, p. 2013

  摘要：

  DOI：

文献信息

• [EN] LIPIDATED CATIONIC PEPTIDE-PEG COMPOSITIONS FOR NUCLEIC ACID DELIVERY<br/>[FR] COMPOSITIONS DE PEPTIDE-PEG CATIONIQUE LIPIDÉ DESTINÉES À L'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：NUTCRACKER THERAPEUTICS INC

  公开号：WO2021030218A1

  公开（公告）日：2021-02-18

  The present disclosure relates to complexes and compositions of cationic compounds combined with low mass percentages of PEGylated compounds, such as PEGylated lipids, for the delivery of nucleic acids and other polyanionic cargoes to cells, methods for preparing complexes and compositions comprising one or more cationic compounds and a low mass percentage of PEGylated compounds with polyanionic compounds, and methods for delivering the polyanionic compounds to cells.

  本公开涉及与PEG化化合物（如PEG化脂质）结合的阳离子化合物复合物和组合物，用于将核酸和其他多阴离子载体传递给细胞，制备包含一种或多种阳离子化合物和低质量百分比PEG化化合物与多阴离子化合物的复合物和组合物的方法，以及将多阴离子化合物传递给细胞的方法。
• METAL-CHELATING COMPOUNDS HAVING AT LEAST ONE POLYAMINO CHAIN
  申请人：UNIVERSITE DE RENNES I

  公开号：US20140364454A1

  公开（公告）日：2014-12-11

  The invention relates to metal-chelating compounds comprising one or more 8-hydroxyquinoline units substituted in position 2 with a nitrogenous group comprising a polyamino chain, wherein the polyamino chain is N-substituted on said nitrogenous group, to the composition containing same, and to the uses thereof in the therapeutic field and in particular in the treatment of diseases associated with an abnormality in the regulation of metal metabolism resulting in a metal overload in human or animal cells.

  该发明涉及含有一个或多个8-羟基喹啉单元的金属螯合化合物，该单元在位置2上被一种氮杂基取代，该氮杂基包括一个聚氨基链，在所述氮杂基上N-取代的聚氨基链，以及含有该化合物的组合物，以及在治疗领域中的用途，特别是在治疗与金属代谢调节异常导致人类或动物细胞中金属超载相关的疾病的用途。
• NEW SQUALAMINE SOLID FORMS AND METHODS OF MAKING THE SAME
  申请人：Enterin, Inc.

  公开号：US20190127416A1

  公开（公告）日：2019-05-02

  Provided herein are crystalline solid forms of squalamine phosphate designated as Form 1 and Form 2, compositions containing one or both forms, and methods of their preparation and of their use.

  本文提供了作为Form 1和Form 2指定的鲨烷磷酸盐的结晶固态形式，包含一种或两种形式的组合物，以及它们的制备方法和使用方法。
• Dielectric Materials and Methods of Preparation and Use Thereof
  申请人：Zheng Yan

  公开号：US20110175089A1

  公开（公告）日：2011-07-21

  Disclosed are dendritic macromolecule-based dielectric compositions (e.g., formulations) and materials (e.g. films) and associated devices. The dendritic macromolecules have branched ends that are functionalized with an organic group that includes at least one 3-40 membered cyclic group.

  本发明涉及基于树枝状大分子的介电组合物（例如配方）和材料（例如薄膜）及其相关设备。所述树枝状大分子具有带有至少一个3-40环成员的有机基团的分支末端。
• Amine-Containing Transfection Reagents and methods for making and using same
  申请人：Yang Zhiwei

  公开号：US20120136073A1

  公开（公告）日：2012-05-31

  There are provided for herein novel amine-containing transfection compounds and methods for making and using same. The compounds are generally obtained by reacting a primary amine with an unsaturated compound. Transfection complexes made using the amine-containing transfection compounds in combination with additional compounds to encapsulate biologically active agents such as nucleic acids are also provided for herein. Methods of using the transfection complexes for the in vivo or in vitro delivery of biologically active agents are also described. The transfection complexes of the present invention are highly potent, thereby allowing effective modulation of a biological activity at relatively low doses compared to analogous transfection compounds known in the art.

  本文提供了一种新型含胺转染化合物及其制备和使用方法。这些化合物通常是通过将一种一级胺与一种不饱和化合物反应而得到的。本文还提供了使用含胺转染化合物与其他化合物结合以封装生物活性物质（如核酸）的转染复合物。还描述了使用该转染复合物进行体内或体外生物活性物质递送的方法。本发明的转染复合物非常有效，因此相对于已知的类似转染化合物，可以在相对较低的剂量下有效调节生物活性。