1-Aethyl-guanin | 55146-00-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 1-Aethyl-guanin
• 英文别名: 1-Ethylguanin；2-amino-1-ethyl-1,7(9)-dihydro-purin-6-one；N'-ethylguanine；2-amino-1-ethyl-7H-purin-6-one
• CAS: 55146-00-4
• 化学式: C₇H₉N₅O
• 分子量: 179.181
• InChiKey: XDCFSKWZZSNAAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  87.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Shape memory polymers
  申请人：Anthamatten Mitchell L.

  公开号：US20080177303A1

  公开（公告）日：2008-07-24

  The present disclosure relates to Shape Memory Polymers (SMP's) comprising function groups that allow the polymers to be elastically deformed, utilized in the elastically deformed state, and subsequently returned to the original polymorphic shape.

  本公开涉及形状记忆聚合物（SMP），其中包含允许聚合物弹性变形的功能基团，可在弹性变形状态下使用，并随后返回到原始的多态形状。
• Shape Memory Polymers
  申请人：Anthamatten Mitchell L.

  公开号：US20110251364A1

  公开（公告）日：2011-10-13

  The present disclosure relates to Shape Memory Polymers (SMP's) comprising function groups that allow the polymers to be elastically deformed, utilized in the elastically deformed state, and subsequently returned to the original polymorphic shape.

  本公开涉及具有功能基团的形状记忆聚合物（SMP），这些功能基团使聚合物能够弹性变形，在弹性变形状态下使用，并随后返回到原始的多形态形状。
• Multifunctional ligand system for cell-specific transfer of nucleic acid
  申请人：HOECHST AKTIENGESELLSCHAFT

  公开号：EP0846772A1

  公开（公告）日：1998-06-10

  The invention relates to a multifunctional ligand system that is not immunogenic and that carries out cell-specific transfer of nucleotide sequences. The system comprises at least one target cell-specific ligand, at least one linker and at least one gene construct-specific ligand, with the gene construct-specific ligand advantageously comprising an antibody, or a part thereof, which binds directly or indirectly to the gene construct. The invention also relates to ligand systems for preparing a pharmaceutical or a vaccine for the treatment or prevention of a disease of the skin, of the mucous membranes, of the nervous system, of the internal organs, of blood coagulation, of the hemopoietic system, of the immune system, of the musculature, of the sustentacular tissue or of the joints.

  本发明涉及一种多功能配体系统，该系统无免疫原性，可进行核苷酸序列的细胞特异性转移。该系统包括至少一种靶细胞特异性配体、至少一种连接体和至少一种基因构建体特异性配体，其中基因构建体特异性配体有利地包括直接或间接与基因构建体结合的抗体或其一部分。本发明还涉及配体系统，用于制备治疗或预防皮肤、粘膜、神经系统、内脏器官、血液凝固、造血系统、免疫系统、肌肉组织、软组织或关节疾病的药物或疫苗。
• Method and test kit for analyzing DNA repair
  申请人：——

  公开号：US20020022228A1

  公开（公告）日：2002-02-21

  A method for analyzing the repair of DNA modifications and base mispairings as well as apurinic and apyrimidinic sites by DNA repair enzymes, comprising the following steps: contacting (a) single- or double-stranded DNA molecules which were covalently coupled to a solid-phase matrix carrying primary or secondary amino groups by reaction with a reactive squaric acid derivative, and which have modifications and/or base mispairings and/or apurinic or apyrimidinic sites, with (b) a composition containing DNA repair enzymes; and determining the elimination of the DNA modifications and/or base mispairings and/or apurinic or apyrimidinic sites. The DNA molecules are covalently coupled to the solid state matrix via a primary or secondary amino group incorporated in the DNA molecule at the 5′-end or at the 3′-end of the DNA or in the 2′-position of at least one deoxyribosyl residue.

  一种分析DNA修复酶对DNA修饰和碱基误配以及嘌呤和嘧啶位点修复的方法，包括以下步骤：将(a)单链或双链DNA分子与(b)含有DNA修复酶的组合物接触，这些DNA分子通过与反应性方酸衍生物反应而共价偶联到带有伯氨基或仲氨基的固相基质上，这些DNA分子具有修饰和/或碱基错配和/或嘌呤或嘧啶位点；并测定DNA修饰和/或碱基错配和/或嘌呤或嘧啶位点的消除情况。DNA 分子通过在 DNA 分子的 5′端、3′端或至少一个脱氧核糖基残基的 2′位加入的伯氨基或仲氨基与固态基质共价偶联。
• Nucleic acids, proteins, and antibodies
  申请人：Human Genome Sciences, Inc.

  公开号：US20030054375A1

  公开（公告）日：2003-03-20

  The present invention relates to novel connective tissue related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as “connective tissue antigens,” and the use of such connective tissue antigens for detecting disorders of connective tissue(s), particularly the presence of cancer and cancer metastases. More specifically, isolated connective tissue associated nucleic acid molecules are provided encoding novel connective tissue associated polypeptides. Novel connective tissue polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human connective tissue associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to connective tissue(s), including cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.

  本发明涉及新型结缔组织相关多核苷酸和由这些多核苷酸编码的多肽，在此统称为 "结缔组织抗原"，以及使用这种结缔组织抗原检测结缔组织疾病，特别是癌症和癌症转移的存在。更具体地说，提供了编码新型结缔组织相关多肽的分离结缔组织相关核酸分子。还提供了新型结缔组织多肽和与这些多肽结合的抗体。本发明还提供了生产人类结缔组织相关多核苷酸和/或多肽的载体、宿主细胞以及重组和合成方法。本发明进一步涉及诊断、治疗、预防和/或预后结缔组织相关疾病（包括癌症）的诊断和治疗方法，以及治疗此类疾病的治疗方法。本发明进一步涉及鉴定本发明多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明进一步涉及抑制本发明多肽的产生和功能的方法和/或组合物。