N-allyl-N-methyl-3β-(2-naphthylcarbamoyl)oxy-7β-hydroxy-12β-((3,5-dinitrophenyl)carbamoyl)oxy-5β-cholan-24-amide | 473530-02-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: N-allyl-N-methyl-3β-(2-naphthylcarbamoyl)oxy-7β-hydroxy-12β-((3,5-dinitrophenyl)carbamoyl)oxy-5β-cholan-24-amide
• CAS: 473530-02-8
• 化学式: C₄₆H₅₇N₅O₁₀
• 分子量: 839.986
• InChiKey: KPYZRANIPOXLAD-HMYYWGPMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.49
• 重原子数：
  61.0
• 可旋转键数：
  12.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  203.48
• 氢给体数：
  3.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  N-allyl-N-methyl-3β-(2-naphthylcarbamoyl)oxy-7β-hydroxy-12β-((3,5-dinitrophenyl)carbamoyl)oxy-5β-cholan-24-amide 在 4-二甲氨基吡啶 、 偶氮二异丁腈 作用下， 以 氯仿 、 甲苯 为溶剂， 反应 36.0h， 生成 N-methyl-N-[3-(3-(trimethoxysilyl)propylthio)propyl]-3β,7β-bis((2-naphthylcarbamoyl)oxy)-12β-((3,5-dinitrophenyl)carbamoyl)oxy-5β-cholan-24-amide
  参考文献：
  名称：

  Synthesis of four cholic acid-based CSPs containing 2-naphthoyl carbamate and 3,5-dinitrophenylcarbamate moieties and their evaluation in the HPLC resolution of racemic compounds

  摘要：

  Four new chiral selectors, obtained by derivatising the hydroxy groups of cholic acid with 2-naphthylisocyanate and 3,5-dinitrophenylisocyanate have been prepared and linked to silica gel to obtain new chiral stationary phases (CSPs) for the HPLC separation of enantiomers. The CSP containing only 2-naphthylcarbamate groups is able to separate the enantiomers of pi-acidic substrates, whereas the CSPs containing one 3,5-dinitrophenylcarbamate group and two 2-naphthyl carbamate moieties resolve pi-acidic racemic compounds as well as pi-basic substrates, with the observed enantiodiscriminating capabilities depending on the arrangement of the different carbamoyl units on the cholestanic backbone. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(02)00317-8
• 作为产物：
  描述：

  2-萘基异氰酸酯 在 4-二甲氨基吡啶 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 32.0h， 生成 N-allyl-N-methyl-3β-(2-naphthylcarbamoyl)oxy-7β-hydroxy-12β-((3,5-dinitrophenyl)carbamoyl)oxy-5β-cholan-24-amide
  参考文献：
  名称：

  Synthesis of four cholic acid-based CSPs containing 2-naphthoyl carbamate and 3,5-dinitrophenylcarbamate moieties and their evaluation in the HPLC resolution of racemic compounds

  摘要：

  Four new chiral selectors, obtained by derivatising the hydroxy groups of cholic acid with 2-naphthylisocyanate and 3,5-dinitrophenylisocyanate have been prepared and linked to silica gel to obtain new chiral stationary phases (CSPs) for the HPLC separation of enantiomers. The CSP containing only 2-naphthylcarbamate groups is able to separate the enantiomers of pi-acidic substrates, whereas the CSPs containing one 3,5-dinitrophenylcarbamate group and two 2-naphthyl carbamate moieties resolve pi-acidic racemic compounds as well as pi-basic substrates, with the observed enantiodiscriminating capabilities depending on the arrangement of the different carbamoyl units on the cholestanic backbone. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(02)00317-8

文献信息

• Effect of the presence of a free hydroxyl group on the enantiodiscrimination properties of cholic acid based CSPs bearing 2-naphthylcarbamate and 3,5-dinitrophenylcarbamate moieties in the HPLC resolution of racemic compounds
  作者：Anna Iuliano、Andrea Ruffini

  DOI：10.1016/j.tetasy.2005.10.036

  日期：2005.11

  Two new chiral selectors, obtained by derivatizing two of the three hydroxyl groups of cholic acid with 2-naphthylisocyanate and 3,5-dinitrophenylisocyanate, have been prepared and linked to silica gel to obtain chiral stationary phases (CSPs) for the HPLC separation of enantiomers. The enantiodiscriminating capability of the two CSPs has been compared to that of the analogous CSP obtained from an exhaustively derivatized cholic acid based selector, in order to establish the effect of the presence of a free hydroxyl group on the enantiodiscrimination properties of this kind of selector. The chromatographic results demonstrate that the enantio selectivity of these selectors strongly depends on the position of the hydroxyl group on the cholestanic backbone. (c) 2005 Elsevier Ltd. All rights reserved.