(2E)-3-pentyl-2-[(Z)-3-(3-pentyl-1,3-benzoxazol-3-ium-2-yl)prop-2-enylidene]-1,3-benzoxazole | 60031-82-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: (2E)-3-pentyl-2-[(Z)-3-(3-pentyl-1,3-benzoxazol-3-ium-2-yl)prop-2-enylidene]-1,3-benzoxazole
• CAS: 60031-82-5
• 化学式: C27H33N2O2+
• 分子量: 417.6
• InChiKey: ZLQJJALHJYCWSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Moyens et procedes de transfert de proteines et/ou d'acides nucleiques sur une surface receptrice supportee
  申请人：PLANT GENETIC SYSTEMS N.V.

  公开号：EP0214909A1

  公开（公告）日：1987-03-18

  L'invention concerne des moyens pour la réception et la retenue sur une surface supportée de protéines et/ou d'acides nucléiques. L'invention consiste à amener à l'état solubilisé des protéines et/ou des acides nucléiques au contact d'une surface libre formée sur un support chimiquement inerte, ladite surface possédant un caractère généralement hydrophobe tout en portant des charges d'un signe déterminé, en présence d'un détergent portant des charges d'un signe opposé au signe déterminé, la concentration du détergent étant suffisante pour maintenir, si besoin, la solubilité desdites protéines et/ou des acides nucléiques, mais ne dépassant pas celle qui entraînerait une fixation trop sélective du détergent à ladite surface, au détriment des protéines et/ou des acides nucléiques.

  本发明涉及在支撑表面接收和保留蛋白质和/或核酸的方法。 本发明包括在带有与给定符号相反符号电荷的洗涤剂存在的情况下，将蛋白质和/或核酸带入与化学惰性支持物上形成的自由表面接触的溶解状态，所述表面一般具有疏水性，同时带有给定符号的电荷、洗涤剂的浓度足以在必要时保持所述蛋白质和/或核酸的溶解度，但不能超过会导致洗涤剂过于选择性地与所述表面结合而损害蛋白质和/或核酸的浓度。
• LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD
  申请人：Watanabe Kohei

  公开号：US20110236310A1

  公开（公告）日：2011-09-29

  The invention provides a labeling composition for an intraocular tissue of a living individual, which specifically labels the intraocular tissue without need of an invasive operation such as exposure of an ocular tissue or injection of a staining agent into the ocular tissue or a nerve tissue linking to the ocular tissue, a method of noninvasively labeling an intraocular tissue of a living individual, and a screening method using the labeling composition for the intraocular tissues. The composition contains a compound capable of labeling at least a photoreceptor cell layer of a retina, wherein the compound is a staining compound having a particular structure as a partial structure thereof.
• ANTI-NEURODEGENERATIVE DISEASE AGENT
  申请人：Ohta Hitomi

  公开号：US20120035187A1

  公开（公告）日：2012-02-09

  The present invention has an object to provide a novel agent for anti-neurodegenerative diseases and solves the object by providing an agent for anti-neurodegenerative diseases containing, as an effective ingredient, the compound(s) represented by the following General formula 1: wherein in General formula 1, R 1 through R 3 independently represent a hydrogen atom or an appropriate substituent; Z 1 represents a heterocyclic ring and Z 2 represents the same or different heterocyclic or aromatic ring as in Z 1 , wherein the heterocyclic and aromatic rings optionally have a substituent; represents an integer of 0, 1 or 2; p represents an integer of 0 or 1, with the proviso that p is 1 when o is 0 or 2, and p is 0 when o is 1; R 1 and R 2 do not exist when o is 0, while, when p is 0, R 3 does not exist and the binding between the carbon atom to which R 2 binds and Z 2 is a single bond; X 1 − represents an appropriate counter anion and q represents an integer of 1 or 2.
• CANCER CELL INHIBITORY DRUG AND CANCER STEM-CELL DETECTION PROBE
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20150182518A1

  公开（公告）日：2015-07-02

  An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. The present invention provides a cancer cell inhibitory drug comprising at least one compound represented by general formula (1) as an active ingredient.
• METHOD OF DETECTING CANCER STEM CELL, METHOD OF SCREENING CANCER STEM CELL, AND METHOD OF INHIBITING CANCER STEM CELL
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20170340622A1

  公开（公告）日：2017-11-30

  An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. The present invention provides a cancer cell inhibitory drug comprising at least one compound represented by general formula (1) as an active ingredient