(R)-2-(aminomethyl)-3-methylbutan-1-ol | 158045-03-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (R)-2-(aminomethyl)-3-methylbutan-1-ol
• 英文别名: (2R)-2-(aminomethyl)-3-methylbutan-1-ol
• CAS: 158045-03-5
• 化学式: C₆H₁₅NO
• 分子量: 117.191
• InChiKey: JUZQUSSFETVSOF-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-2-(aminomethyl)-3-methylbutan-1-ol 在 Jones reagent 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 1.0h， 生成 (R)-Fmoc-2-氨乙基-3-甲基丁酸盐酸盐
  参考文献：
  名称：

  Hairpin Folding Behavior of Mixed α/β-Peptides in Aqueous Solution

  摘要：

  The invention of new strategies for the design of protein-mimetic oligomers that manifest the folding encoded in natural amino acid sequences is a significant challenge. In contrast to the a-helix, mimicry of protein beta-sheets is less understood. We report here the aqueous folding behavior of a prototype alpha-peptide hairpin model sequence varied at cross-strand positions by incorporation of 16 different beta-amino acid monomers. Our results provide a folding propensity scale for beta-residues in a protein beta-sheet context as well as high-resolution structures of several mixed-backbone alpha/beta-peptide hairpins in water.

  DOI：

  10.1021/ja2002346
• 作为产物：
  描述：

  在 palladium on carbon 、 甲酸铵 作用下， 以 甲醇 为溶剂， 反应 5.0h， 生成 (R)-2-(aminomethyl)-3-methylbutan-1-ol
  参考文献：
  名称：

  Hairpin Folding Behavior of Mixed α/β-Peptides in Aqueous Solution

  摘要：

  The invention of new strategies for the design of protein-mimetic oligomers that manifest the folding encoded in natural amino acid sequences is a significant challenge. In contrast to the a-helix, mimicry of protein beta-sheets is less understood. We report here the aqueous folding behavior of a prototype alpha-peptide hairpin model sequence varied at cross-strand positions by incorporation of 16 different beta-amino acid monomers. Our results provide a folding propensity scale for beta-residues in a protein beta-sheet context as well as high-resolution structures of several mixed-backbone alpha/beta-peptide hairpins in water.

  DOI：

  10.1021/ja2002346

文献信息

• METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND
  申请人：Matsuda Koji

  公开号：US20090036684A1

  公开（公告）日：2009-02-05

  The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2′): wherein R is a fluorine atom or a methoxy group, and R 400 is a hydrogen atom or a C 1 -C 4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.

  本发明提供了一种化合物，可用作抗HIV剂的合成中间体，具有整合酶抑制活性，以及其生产方法和使用该合成中间体生产抗HIV剂的方法。具体而言，例如，化合物由式（2'）表示：其中R为氟原子或甲氧基，R400为氢原子或C1-C4烷基，或其盐，以及其生产方法和使用该合成中间体生产抗HIV剂的方法。
• US8383819B2
  申请人：——

  公开号：US8383819B2

  公开（公告）日：2013-02-26