3'-Azido-2',3'-dideoxyguanosine 5'-(dihydrogen phosphate) | 72189-88-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 3'-Azido-2',3'-dideoxyguanosine 5'-(dihydrogen phosphate)
• 英文别名: [(2S,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-azidooxolan-2-yl]methyl dihydrogen phosphate
• CAS: 72189-88-9
• 化学式: C10H13N8O6P
• 分子量: 372.23
• InChiKey: RXJJJCHGURHZCO-KVQBGUIXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  176
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• PURINE NUCLEOSIDE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF CANCER AND VIRAL INFECTIONS
  申请人：RFS Pharma, LLC.

  公开号：EP2393815A2

  公开（公告）日：2011-12-14
• US5563257A
  申请人：——

  公开号：US5563257A

  公开（公告）日：1996-10-08
• US5756711A
  申请人：——

  公开号：US5756711A

  公开（公告）日：1998-05-26
• [EN] PURINE NUCLEOSIDE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF CANCER AND VIRAL INFECTIONS<br/>[FR] PROMÉDICAMENTS À BASE DE PURINE NUCLÉOSIDE MONOPHOSPHATE POUR LE TRAITEMENT DU CANCER ET DES INFECTIONS VIRALES
  申请人：RFS PHARMA LLC

  公开号：WO2010091386A2

  公开（公告）日：2010-08-12

  The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporo virus, HSV-I, HSV-2, Dengue virus, Yellow fever, and HBV in human patients or other animal hosts. The compounds are certain 6-substituted purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-I, HIV-2, HCV, Norovirus, Saporovirus, HSV-I, HSV-2, Dengue virus, Yellow fever, and HBV.