[1-(1-Acetyloxynaphthalen-2-yl)naphthalen-2-yl] acetate | 1227735-74-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: [1-(1-Acetyloxynaphthalen-2-yl)naphthalen-2-yl] acetate
• CAS: 1227735-74-1
• 化学式: C₂₄H₁₈O₄
• 分子量: 370.405
• InChiKey: PSWAFYQSENZXCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙酸酐 、 [1,2'-binaphthalene]-1',2-diol 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 生成 [1-(1-Acetyloxynaphthalen-2-yl)naphthalen-2-yl] acetate
  参考文献：
  名称：

  Synthesis of Unsymmetrical o-Biphenols and o-Binaphthols via Silicon-Tethered Pd-Catalyzed C−H Arylation

  摘要：

  A mild, practical, and efficient method for the synthesis of unsymmetrical o-biphenols (including o-phenol-naphthols and o-binaphthols) has been developed. Unsymmetrical bis-aryloxy silanes, which were readily prepared in a semi-one-pot fashion, underwent the Pd-catalyzed intramolecular arylation followed by a routine TBAF desilylation step to furnish valuable unsymmetrical biphenols without necessity of isolation of seven-membered intermediates. The excellent functional group tolerance allows for synthesis of a variety of functionalized o-biphenols and o-binaphthols from easily available staring materials.

  DOI：

  10.1021/ol100924n