3β-phenylcholestane | 103475-54-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β-phenylcholestane
• 英文别名: 3β-phenyl-5α-cholestane；3β-Phenyl-5α-cholestan；(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-3-phenyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene
• CAS: 103475-54-3
• 化学式: C₃₃H₅₂
• 分子量: 448.776
• InChiKey: BPJSKGKQNCKLSC-VQWCBXCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.3
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  3β-phenylcholestane 在 乙醚 、 溶剂黄146 、 铂 作用下， 生成 3β-cyclohexyl-5α-cholestane
  参考文献：
  名称：

  Brine Disposal from Inland Desalination Plants

  摘要：

  Desalination plants are being widely used in the inland areas of many countries to supply water for domestic purposes. When these areas are far from the shorelines of salt-water bodies, the opportunity to dispose of the reject brine (also known as concentrate, reject water, or wastewater) back into these water bodies no longer exists, In such instances, the use of evaporation ponds is very significant, both economically and environmentally. Other alternatives for brine disposal may also be very effective in some instances. Under certain conditions, brine from desalination plants can have useful applications. Potentials for such applications are addressed in this paper along with a critical review of current innovative concepts for the disposal of reject brine from inland desalination plants. This paper will also assess the present status of disposal mechanisms of brine from desalination plants and outline future research areas that could be pursued for effective, economical, and environmentally sound means for brine disposal from such plants.

  DOI：

  10.1080/02508060208686992
• 作为产物：
  描述：

  苯 、 alkaline earth salt of/the/ methylsulfuric acid 在 三氯化铝 作用下， 生成 3β-phenylcholestane
  参考文献：
  名称：

  Kawasaki, Yakugaku Zasshi, 1937, vol. 57, p. 949,951; dtsch. Ref. S. 268

  摘要：

  DOI：

文献信息

• Teaching an old carbocation new tricks: Intermolecular C–H insertion reactions of vinyl cations
  作者：Stasik Popov、Brian Shao、Alex L. Bagdasarian、Tyler R. Benton、Luyi Zou、Zhongyue Yang、K. N. Houk、Hosea M. Nelson

  DOI：10.1126/science.aat5440

  日期：2018.7.27

  find that these reactive intermediates undergo mild intermolecular carbon-carbon bond–forming reactions, including carbon-hydrogen (C–H) insertion into unactivated sp3 C–H bonds and reductive Friedel-Crafts reactions with arenes. Moreover, we conducted computational studies of these alkane C–H functionalization reactions and discovered that they proceed through nonclassical, ambimodal transition structures

  硅为乙烯基阳离子铺平道路 饱和碳中心通常通过碳-卤素键或碳-氧键的初始裂解发生取代反应，从而使碳带正电。事实证明，从参与双键的乙烯基碳中很难接触到类似的阳离子。Popov 等人现在表明，硅阳离子与非配位阴离子配对可以在环境条件下从这种乙烯基碳中拉出三氟甲磺酸基团（参见 Kennedy 和 Klumpp 的观点）。所得乙烯基阳离子通过 C-H 插入与简单烷烃反应。理论和机理研究表明，这些反应通过非经典途径进行，这些途径在过渡态后分叉。科学，本期，第 381 页;另见第 331 页硅阳离子从烯烃中吸出三氟甲磺酸取代基，形成乙烯基阳离子，通过 C-H 插入与烷烃反应。在过去的五十年里，乙烯基碳阳离子一直是广泛的实验和理论研究的主题。尽管在化学领域有着悠久的历史，但乙烯基阳离子在化学合成中的效用一直受到限制，大多数反应性研究都集中在溶解反应或分子内过程上。在这里，我们报告了通过硅烷弱配位阴离子催化
• Synthesis of alkylbenzenes by Friedel-Crafts reactions catalysed by K10-montmorillonite
  作者：Odette Sieskind、Pierre Albrecht

  DOI：10.1016/s0040-4039(00)77527-7

  日期：1993.2

  Monoalkylation of benzene with primary, secondary and tertiary alcohols took place in high yields when K10-montmorillonite was used as acidic catalyst. Unexpected formation of 1-phenylalkylbenzenes occurred, beside other isomers with primary alcohols. Monoalkylation with cholestanol and cholesterol was regiospecific and located at C-3. Clay-catalysed alkylbenzene formation may also be of geochemical interest.
• Kawasaki, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1937, vol. 57, p. 713,714; dtsch. Ref. S. 162, 268
  作者：Kawasaki

  DOI：——

  日期：——
• Kawasaki; Yamamura, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1939, vol. 59, p. dtsch. Ref. S. 144, 152
  作者：Kawasaki、Yamamura

  DOI：——

  日期：——
• Hattori; Kawasaki, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1937, vol. 57, p. 588,590; dtsch. Ref. S. 115
  作者：Hattori、Kawasaki

  DOI：——

  日期：——