2-Dimethylamino-9-methyl-purin | 32364-21-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-Dimethylamino-9-methyl-purin
• 英文别名: N,N,9-trimethylpurin-2-amine
• CAS: 32364-21-9
• 化学式: C₈H₁₁N₅
• 分子量: 177.209
• InChiKey: MJVAUDLKQUCYCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  46.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• CYCLIC DINUCLEOTIDE COMPOUND AND USES THEREOF
  申请人：SHANGHAI JEMINCARE PHARMACEUTICALS CO., LTD.

  公开号：US20210340169A1

  公开（公告）日：2021-11-04

  Provided are a compound of formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, uses of said compound acting as a STING agonist.

  提供的是化合物（I）的化学式，其光学异构体，其药用盐，以及作为STING激动剂的该化合物的用途。
• [EN] LIPID COMPOSITIONS FOR DELIVERY OF STING AGONIST COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSITIONS LIPIDIQUES POUR L'ADMINISTRATION DE COMPOSÉS AGONISTES DE STING ET LEURS UTILISATIONS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2021216572A1

  公开（公告）日：2021-10-28

  The present disclosure provides lipid compositions comprising lipid particles (e.g., lipid nanodiscs), wherein the lipid particles (e.g., lipid nanodiscs) comprise a STING agonist amphiphile conjugate, a phospholipid and a PEG-lipid. The compositions are used in methods to induce or promote immune responses, such as immune responses useful for the treatment of cancer or infectious disease.

  本公开提供了包含脂质粒子（例如脂质纳米盘）的脂质组合物，其中脂质粒子（例如脂质纳米盘）包含STING激动剂两亲分子共轭物、磷脂和PEG-脂质。该组合物用于诱导或促进免疫反应，例如用于治疗癌症或传染病的免疫反应。
• Cyclic di-nucleotide compounds as STING agonists
  申请人：Merck Sharp & Dohme Corp.

  公开号：US10738074B2

  公开（公告）日：2020-08-11

  A class of polycyclic compounds of general formula (II), of general formula (II′), or of general formula (II″), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

  一类通式(II)、通式(II′)或通式(II″)的多环化合物，其中Base1、Base2、Y、Ya、Xa、Xa1、Xb、Xb1、Xc、Xc1、Xd、Xd1、R1、R1a、本文定义了 R2、R2a、R3a、R4、R4a、R5、R6、R6a、R7、R7a、R8 和 R8a，它们可用作 I 型干扰素产生的诱导剂，特别是 STING 活性剂。还提供了合成和使用这些化合物的工艺。
• Cyclic dinucleotide
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US10980825B2

  公开（公告）日：2021-04-20

  The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

  本公开提供了一种具有 STING 激动活性的化合物，该化合物有望用作预防或治疗 STING 相关疾病的药物。 本公开涉及一种由式（I）表示的化合物： 其中各符号如描述中所定义，或其盐类。
• CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20170044206A1

  公开（公告）日：2017-02-16

  A class of polycyclic compounds of general formula (I), of general formula (I′), or of general formula (I″), wherein Base 1 , Base 2 , Y, Y a , X a , X a1 , X b , X b1 , X c , X c1 , X d , X d1 , R 1 , R 1a , R 2 , R 2a , R 3 , R 4 , R 4a , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , and R 8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.