氢化可的松-[1,2,6,7-3H(N)] | 70094-60-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 氢化可的松-[1,2,6,7-3H(N)]
• 英文名称: [3H]-Hydrocortisone
• 英文别名: [1,2,6,7-3H]-cortisol；1,2,6,7-(3H)Cortisol；(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7-tetratritio-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
• CAS: 70094-60-9
• 化学式: C₂₁H₃₀O₅
• 分子量: 370.434
• InChiKey: JYGXADMDTFJGBT-YPISDNQJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 危险品标志：
  Xn,R,F
• 安全说明：
  S16,S23,S26,S36
• 危险类别码：
  R11,R36/37/38,R63

反应信息

• 作为反应物：
  描述：

  氢化可的松-[1,2,6,7-3H(N)] 在 重铬酸吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 44.0h， 生成 [1,2,6,7-3H]adrenosterone
  参考文献：
  名称：

  A simple two-step method for the conversion of [3H]cortisol to [3H]-11-ketotestosterone

  摘要：

  Despite the existence of several protocols, problems appear to persist in the small scale chemical synthesis of radiolabeled 11-ketotestosterone from cortisol. We investigated the possibilities of using the mild oxidant pyridinium dichromate for the oxidative cleavage of the dihydroxyacetone side chain of cortisol and 17 beta-hydroxysteroid dehydrogenase for the subsequent reduction of the resulting 17-keto group. Our protocol has resulted in consistently high yields of both the intermediate, adrenosterone (70-80%), and the product, 11-ketotestosterone (up to 60%). This, taken together with the convenience and relatively low cost of our method, recommends the protocol for its use for the synthesis of [H-3]-11-ketotestosterone for endocrine studies. (C) 1997 by Elsevier Science Inc.

  DOI：

  10.1016/s0039-128x(97)00052-4

文献信息

• [EN] INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 AND TYPE 2<br/>[FR] INHIBITEURS DE 11-BETA-HYDROXY STEROIDE DEHYDROGENASE DE TYPE 1 ET DE TYPE 2
  申请人：STERIX LTD

  公开号：WO2004037251A1

  公开（公告）日：2004-05-06

  There is provided a compound having Formula (I): wherein one of R1 and R2 is a group of the Formula (a), wherein R4 is selected from H and hydrocarbyl, R5 is a hydrocarbyl group and L is an optional linker group, or R1 and R2 together form a ring substituted with the group (Formula (a)) wherein R3 is H or a substituent, and wherein X is selected from S, O, NR6 and C(R7)(R8), wherein R6 is selected from H and hydrocarbyl groups, wherein each of R7 and R8 are independently selected from H and hydrocarbyl groups.

  提供一种具有化学式(I)的化合物：其中R1和R2中的一个是化学式(a)的基团，其中R4从H和烃基中选择，R5是烃基，L是可选的连接基团，或者R1和R2一起形成一个环，该环被基团(FORMULA (a))取代，其中R3是H或取代基，X从S、O、NR6和C(R7)(R8)中选择，其中R6从H和烃基中选择，R7和R8分别从H和烃基中独立选择。
• [EN] GLYCYRRHETINIC ACID AMINE ANALOGUES FOR USE IN THE TREATMENT OF INFLAMMATION, INFECTIOUS DISEASES, CANCER, AUTOIMMUNE DISEASES, SKIN DISEASES, BONE DISEASES AND METABOLIC DISEASES<br/>[FR] ANALOGUES AMINE D'ACIDE GLYCYRRHÉTINIQUE DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE L'INFLAMMATION, DES MALADIES INFECTIEUSES, DU CANCER, DES MALADIES AUTO-IMMUNES, DES MALADIES DE LA PEAU, DES MALADIES DES OS ET DES MALADIES MÉTABOLIQUES
  申请人：ONEPHARM RES & DEV GMBH

  公开号：WO2012020021A9

  公开（公告）日：2012-05-10