N-[2-[1-[2-[2-[(2,3-dihydroxybenzoyl)amino]ethoxy]naphthalen-1-yl]naphthalen-2-yl]oxyethyl]-2,3-dihydroxybenzamide | 1325717-71-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[2-[1-[2-[2-[(2,3-dihydroxybenzoyl)amino]ethoxy]naphthalen-1-yl]naphthalen-2-yl]oxyethyl]-2,3-dihydroxybenzamide
• CAS: 1325717-71-2
• 化学式: C₃₈H₃₂N₂O₈
• 分子量: 644.681
• InChiKey: UHQOFGAZGOVZOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  48
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  158
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N-[2-[1-[2-[2-[(2,3-dihydroxybenzoyl)amino]ethoxy]naphthalen-1-yl]naphthalen-2-yl]oxyethyl]-2,3-dihydroxybenzamide 在 硫酸 作用下， 反应 16.0h， 以75%的产率得到
  参考文献：
  名称：

  Sequestering agent for uranyl chelation: new binaphtyl ligands

  摘要：

  The synthesis of phosphonate, sulfocatecholamide (CAMS) and hydroxypyridinone (HOPO) binaphtyl ligands is presented. Their binding abilities for uranyl cation were determined by UV spectrophotometry in aqueous media versus pH. These titrations showed that the efficiency of these chelating agents depends on the nature of the chelating group. Each ligand shows a more or less pronounced affinity towards uranium. While the bisphosphonate compound did not show any affinity towards the uranyl ion, the BINHOPO derivative exhibits significant affinity at acidic and neutral pH while the BINCAMS is more efficient at basic pH. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.05.075
• 作为产物：
  描述：

  2,3-bis(benzyloxy)benzoyl chloride 在 10% palladium on activated charcoal 、 氢气 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 54.0h， 生成 N-[2-[1-[2-[2-[(2,3-dihydroxybenzoyl)amino]ethoxy]naphthalen-1-yl]naphthalen-2-yl]oxyethyl]-2,3-dihydroxybenzamide
  参考文献：
  名称：

  Sequestering agent for uranyl chelation: new binaphtyl ligands

  摘要：

  The synthesis of phosphonate, sulfocatecholamide (CAMS) and hydroxypyridinone (HOPO) binaphtyl ligands is presented. Their binding abilities for uranyl cation were determined by UV spectrophotometry in aqueous media versus pH. These titrations showed that the efficiency of these chelating agents depends on the nature of the chelating group. Each ligand shows a more or less pronounced affinity towards uranium. While the bisphosphonate compound did not show any affinity towards the uranyl ion, the BINHOPO derivative exhibits significant affinity at acidic and neutral pH while the BINCAMS is more efficient at basic pH. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.05.075

文献信息

• Sequestering agent for uranyl chelation: new binaphtyl ligands
  作者：Antoine Leydier、Delphine Lecerclé、Stéphane Pellet-Rostaing、Alain Favre-Reguillon、Frédéric Taran、Marc Lemaire

  DOI：10.1016/j.tetlet.2011.05.075

  日期：2011.8

  The synthesis of phosphonate, sulfocatecholamide (CAMS) and hydroxypyridinone (HOPO) binaphtyl ligands is presented. Their binding abilities for uranyl cation were determined by UV spectrophotometry in aqueous media versus pH. These titrations showed that the efficiency of these chelating agents depends on the nature of the chelating group. Each ligand shows a more or less pronounced affinity towards uranium. While the bisphosphonate compound did not show any affinity towards the uranyl ion, the BINHOPO derivative exhibits significant affinity at acidic and neutral pH while the BINCAMS is more efficient at basic pH. (C) 2011 Elsevier Ltd. All rights reserved.