1-(4-chlorophenyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide | 1221686-08-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 1-(4-chlorophenyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide
• CAS: 1221686-08-3
• 化学式: BrH*C₁₅H₁₄ClNO₂
• 分子量: 356.647
• InChiKey: UCGWTCIUWJQFMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.56
• 重原子数：
  20.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  52.49
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  2-(3,4-二羟基苯基)乙胺 氢溴酸盐 、 4-氯苯甲醛 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 48.0h， 生成 1-(4-chlorophenyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide
  参考文献：
  名称：

  1-Phenylisoquinoline larvicidal activity againstCulex quinquefasciatus

  摘要：

  The larvicidal potential of several dopamine 1-phenylisoquinoline derivatives against Culex quinquefasciatus third instar larvae was investigated in a rational search for insecticides. The results showed that these isoquinolines presented moderate larvicidal activity, that the presence of a substituent is needed on carbon 1 for such activity to be presented and that it may be possible to develop novel insecticidal compounds having potential use in controlling insects by appropriate structural modification of 1-phenylisoquinolines. This article presents a possible structure-larvicidal activity relationship for isoquinolinic compounds.

  DOI：

  10.1080/14786419.2011.560846