N5-methyl-5-amino-2,3-dihydrophthalazine-1,4-dione | 7600-09-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N5-methyl-5-amino-2,3-dihydrophthalazine-1,4-dione
• 英文别名: 5-methylamino-2,3-dihydrophthalazine-1,4-dione；5--2,3-dihydro-1,4-phthalazindion；3-Methylamino-phthalhydrazid；5-Methylamino-2,3-dihydro-phthalazin-1,4-dion；4-Hydroxy-8-(methylamino)phthalazin-1(2H)-one；5-(methylamino)-2,3-dihydrophthalazine-1,4-dione
• CAS: 7600-09-1
• 化学式: C₉H₉N₃O₂
• 分子量: 191.189
• InChiKey: VOQOISCWQWDUCM-UHFFFAOYSA-N

物化性质

• 密度：
  1.358±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  70.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 一水合肼 作用下， 生成 N5-methyl-5-amino-2,3-dihydrophthalazine-1,4-dione
  参考文献：
  名称：

  132.化学发光有机化合物。第四部分 氨基和肼基环邻苯二甲酰肼及其相对发光功率

  摘要：

  DOI：

  10.1039/jr9370000586

文献信息

• COMPOSITIONS AND METHODS FOR MEASURING OXIDATIVE STRESS
  申请人：Washington University

  公开号：US20210386874A1

  公开（公告）日：2021-12-16

  The present disclosure provides for imaging agents and methods of making and using the same. The imaging agent comprises a luminol component comprising a luminol moiety or functional analogue thereof; a chelator; a linker group bonding or complexing the luminol component to the chelator; and a radiolabel component bound to the chelator. The imaging agent described herein is capable of monitoring, targeting, or imaging oxidative stress, reactive oxygen species (ROS), superoxide generation, or hydrogen peroxide generation, mediating pathophysiology of different disease states.

  本公开提供了成像剂及其制备和使用的方法。该成像剂包括一种亮氨酮组分，包括亮氨酮基团或其功能类似物；螯合剂；将亮氨酮组分与螯合剂结合或络合的连接器基团；以及结合到螯合剂上的放射性标记组分。本文所描述的成像剂能够监测、定位或成像氧化应激、反应性氧化物种（ROS）、超氧离子生成或过氧化氢生成，介导不同疾病状态的病理生理学。
• PHARMACEUTICAL GRADE PHTHALAZINEDIONES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：BACH PHARMA, INC

  公开号：US20160237039A1

  公开（公告）日：2016-08-18

  The present invention comprises methods of manufacturing a highly purified, pharmaceutical grade phthalazinedione for administration to a human or animal. The manufacturing methods identify and isolate starting materials, and prepare intermediate products, which are suitable for the commercial batch process production of highly purified and high-yielding intermediate products and final phthalazinedione products.

  本发明涉及制造高纯度、制药级邻苯二酮衍生物的方法，以供人类或动物使用。制造方法通过识别和分离起始材料，并制备中间产物，适用于商业批量生产高纯度和高产率的中间产物和最终邻苯二酮衍生物产品。
• Method for correcting immune system of live body
  申请人：——

  公开号：US20030195183A1

  公开（公告）日：2003-10-16

  The present invention relates to medicine and veterinary, namely, to immunology, and to methods aimed at correcting the immune system of a living organism. The essence of the invention is in the immunocorrection of the organism using pharmacologically appropriate amino derivatives of 2,3-dihydrophthalazine-1,4˜dione in their effective doses ranging from 0.2 &mgr;g to 1,000 mg.

  本发明涉及医学和兽医学，即免疫学，以及旨在纠正生物体免疫系统的方法。本发明的精髓在于使用药理上适当的 2,3-二氢酞嗪-1,4˜二酮的氨基衍生物对生物体进行免疫矫正，其有效剂量从 0.2 毫克到 1,000 毫克不等。
• Modulation of cell fates and activities by phthalazinediones
  申请人：Henry O. Mark

  公开号：US20050288291A1

  公开（公告）日：2005-12-29

  Phthalazinediones that function as intracellular redox modulators are useful in treating cells in various disease states where intracellular redox status is impaired. By buffering aberrant redox states, phthalazinediones enable cellular processes essential for survival and augment medical treatments. The phthalazinediones of the invention can modulate functions related to cell growth, differentiation, activity, or death, to correct aberrations and restore homeostasis, and can serve as adjunctive therapy in treating various disease conditions.

  作为细胞内氧化还原调节剂的酞嗪二酮类化合物可用于治疗细胞内氧化还原状态受损的各种疾病状态下的细胞。通过缓冲失常的氧化还原状态，酞嗪二酮类化合物能使细胞进行生存所必需的过程，并增强医疗效果。本发明的酞嗪二酮类化合物可以调节与细胞生长、分化、活性或死亡有关的功能，纠正畸变和恢复平衡，并可作为治疗各种疾病的辅助疗法。
• Gleu; Pfannstiel, Journal fur praktische Chemie (Leipzig 1954), 1936, vol. <2> 146, p. 129,134, 136
  作者：Gleu、Pfannstiel

  DOI：——

  日期：——