α-aminoisobutylphosphonous acid | 67896-52-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: α-aminoisobutylphosphonous acid
• 英文别名: 1-Aminoisobutylphosphonous acid；1-amino-2-methylpropylphosphinic acid；(RS)-1-amino-2-methylpropylphosphinic acid；(1-amino-2-methyl-propyl)-phosphonous acid；(1-Amino-2-methylpropyl)phosphinic acid
• CAS: 67896-52-0
• 化学式: C₄H₁₂NO₂P
• 分子量: 137.119
• InChiKey: KBMNZBMTGZTXAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  69.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  α-aminoisobutylphosphonous acid 在 diclazuril 、 重水 作用下， 生成
  参考文献：
  名称：

  Study of exchange of hydrogen for deuterium and tritium in ?-aminoalkylphosphonous acids

  摘要：

  The kinetics of isotope exchange of hydrogen for deuterium in alpha-aminoalkylphosphonous acids as a function of the pH were investigated by PMR spectroscopy. Tritium-labeled alpha-aminoalkylphosphonous acids were obtained as a result of direct hydrogen-tritium exchange between T2O and hydrophosphoryl compounds.

  DOI：

  10.1007/bf00958237
• 作为产物：
  描述：

  [1-(Benzhydrylidene-amino)-2-methyl-propyl]-diethoxymethyl-phosphinic acid ethyl ester 在 盐酸 作用下， 生成 α-aminoisobutylphosphonous acid
  参考文献：
  名称：

  McCleery, Patrick P.; Tuck, Brian, Journal of the Chemical Society. Perkin transactions I, 1989, p. 1319 - 1329

  摘要：

  DOI：

文献信息

• Phosphonic acid derivatives having carboxypeptidase b inhibitory activity
  申请人：Meiji Seika Kaisha Ltd.

  公开号：US06576627B1

  公开（公告）日：2003-06-10

  A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R1 represents hydrogen atom, an alkyl group, a substituted alkyl group and the like; R2 and R3 represent hydrogen atom, an alkyl group, a substituted alkyl group, an alkoxyl group and the like; X represents —CH2—, —O—, or —NH—; A represents the following group (II): [in which R7 and R8 represent hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group and the like; R9 and R10 represents hydrogen atom, a halogen atom, hydroxyl group, phenyl group, an alkyl group and the like] and the like; and E represents hydrogen atom and the like, which has inhibitory activity against carboxypeptidase B and is useful for therapeutic and/or preventive treatment of a thrombotic disease.

  以下是通用公式（I）及其药理学上可接受的盐所代表的化合物： 其中R1代表氢原子、烷基、取代烷基等；R2和R3代表氢原子、烷基、取代烷基、烷氧基等；X代表—CH2—、—O—或—NH—；A代表以下的基团（II）： 【其中R7和R8代表氢原子、烷基、酰基、烷氧羰基等；R9和R10代表氢原子、卤素原子、羟基、苯基、烷基等】等；E代表氢原子等，具有对羧肽酶B的抑制活性，并且对治疗和/或预防血栓性疾病有用。
• Application of in Situ Silylation for Improved, Convenient Preparation of Fluorenylmethoxycarbonyl (Fmoc)-Protected Phosphinate Amino Acids
  作者：Li、John K. Whitehead、Robert P. Hammer

  DOI：10.1021/jo070266p

  日期：2007.4.1

  A convenient and efficient method has been developed for the preparation of 9-fluorenylmethoxycarbonyl (Fmoc)-protected 1-aminoalkylphosphinic acids. Reproducible procedures for the synthesis and purification of free α-amino H-phosphinates are provided. Protection of free amino phosphinates as the N-Fmoc derivative was achieved by in situ trimethylsilylation of aminoalkylphosphinic acids, which then

  已经开发了一种方便且有效的方法来制备9-芴基甲氧基羰基（Fmoc）保护的1-氨基烷基次膦酸。提供了用于游离α-氨基H-次膦酸酯的合成和纯化的可再现程序。通过氨基烷基次膦酸的原位三甲基甲硅烷基化来保护游离氨基次膦酸酯作为N -Fmoc衍生物，然后将其与Fmoc-Cl反应，以简单的萃取分离后，就可以以优异的收率和高纯度提供相应的产物。讨论了甲硅烷基化的机理，并介绍了该方法在另一类氨基磷酸中的应用。
• Compounds and methods for protease detection
  申请人：Martin Stella Lorraine

  公开号：US09340820B2

  公开（公告）日：2016-05-17

  Alternative methods for the detection and measurement of proteases in biological samples and compounds which allow for such detection are required to allow for rapid and selective identification of these enzymes. Compounds which allow for selective identification of these enzymes are provided with assays and kits for their use.

  需要提供用于生物样本中蛋白酶检测和测量的替代方法和允许进行快速和选择性酶识别的化合物，以便提供这些酶的快速和选择性识别。提供了允许对这些酶进行选择性识别的化合物，并提供了用于其使用的检测和试剂盒。
• A Novel Synthetic Route to 1-Aminoalkylphosphinic Acids
  作者：Xian-Yun Jiao、Christophe Verbruggen、Marianne Borloo、Willy Bollaert、Alex De Groot、Roger Dommisse、Achiel Haemers

  DOI：10.1055/s-1994-25395

  日期：——

  A "one-pot" synthesis of various 1-aminoalkylphosphinic acids is described. They were obtained in high yield by the deprotection of the corresponding bis(trimethylsilyl) N-tritylaminoalkylphosphites. The latter were prepared by addition of bis(trimethylsilyl) phosphonite to a Ntritylalkanimine.

  本研究描述了各种 1-氨基烷基膦酸的 "一步法 "合成。通过对相应的双（三甲基硅基）N-三苯甲基氨基烷基膦酸进行脱保护，可以获得高产率的 1-氨基烷基膦酸。后者是通过将双（三甲基硅基）亚磷酸加到 N-三苯甲基烷基氨基中制备的。
• Phosphinate Inhibitors of UDP-N-Acetylmuramoyl-L-Alanyl-D-Glutamate:L-Lysine Ligase (MurE)
  作者：Katja Štrancar、Audrey Boniface、Didier Blanot、Stanislav Gobec

  DOI：10.1002/ardp.200600191

  日期：2007.3

  attention on the Mur ligases (MurC‐F), which catalyze the early steps of bacterial peptidoglycan biosynthesis, and which to date represent under‐exploited targets for antibacterial drug design. We show that some of our phosphinate inhibitors of UDP‐N‐acetylmuramoyl‐L‐alanyl:D‐glutamate ligase (MurD) also inhibits UDP‐N‐acetylmuramoyl‐L‐alanyl‐D‐glutamate:L‐lysine ligase (MurE). To obtain new information

  对抗生素治疗具有高抗性的病原菌株的日益出现，迫切需要开发针对新靶点的新型抗菌剂。我们将注意力集中在 Mur 连接酶 (MurC-F) 上，它催化细菌肽聚糖生物合成的早期步骤，并且迄今为止代表了尚未开发的抗菌药物设计目标。我们展示了我们的一些 UDP-N-乙酰胞壁酰-L-丙氨酰：D-谷氨酸连接酶 (MurD) 的次膦酸盐抑制剂也抑制 UDP-N-乙酰胞壁酰-L-丙氨酰-D-谷氨酸：L-赖氨酸连接酶 (MurE)。为了获得有关其构效关系的新信息，合成了三种新的、结构相关的次膦酸盐并评估了对 MurD 和 MurE 的抑制作用。