quinazoline-1-oxide | 89939-26-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: quinazoline-1-oxide
• 英文别名: 1-hydroxy-1H-quinazolin-4-one；4(3H)-Chinazolinon-1-oxyd
• CAS: 89939-26-4
• 化学式: C₈H₆N₂O₂
• 分子量: 162.148
• InChiKey: RSGBLIRRHFJXME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.16
• 重原子数：
  12.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  59.8
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  quinazoline-1-oxide 、 alkaline earth salt of/the/ methylsulfuric acid 在 potassium carbonate 、 sodium iodide 作用下， 以 丙酮 为溶剂， 反应 24.0h， 生成 3-[3-(piperidin-1-yl)propyl]-4-oxo-3,4-dihydroquinazoline-1-oxide
  参考文献：
  名称：

  Novel bronchodilatory quinazolines and quinoxalines: Synthesis and biological evaluation

  摘要：

  A series of heterocyclic derivatives analogous to (-)vasicinone, in which the vasicinone C-ring was replaced with alkyl chain terminated by tertiary amine was prepared. N3, C4-O, C4-S or C4-N were used as the sites of attachment. The 4-[3-(1-piperidyl)propylsulfanyl]derivatives displayed bronchodilatory effect at low micromolar concentrations on isolated rat trachea, and low toxicity both on Balb/c 3T3 mouse fibroblast cells and in mice. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.12.024
• 作为产物：
  描述：

  4-羟基喹唑啉 在 硫酸 、 双氧水 作用下， 以 水 为溶剂， 反应 8.0h， 生成 quinazoline-1-oxide
  参考文献：
  名称：

  Novel bronchodilatory quinazolines and quinoxalines: Synthesis and biological evaluation

  摘要：

  A series of heterocyclic derivatives analogous to (-)vasicinone, in which the vasicinone C-ring was replaced with alkyl chain terminated by tertiary amine was prepared. N3, C4-O, C4-S or C4-N were used as the sites of attachment. The 4-[3-(1-piperidyl)propylsulfanyl]derivatives displayed bronchodilatory effect at low micromolar concentrations on isolated rat trachea, and low toxicity both on Balb/c 3T3 mouse fibroblast cells and in mice. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.12.024

文献信息

• [EN] QUINAZOLINONE T-TYPE CALCIUM CHANNEL ANTAGONISTS<br/>[FR] ANTAGONISTES DE CANAL CALCIQUE DE TYPE T AU QUINAZOLINONE
  申请人：MERCK & CO INC

  公开号：WO2009009015A1

  公开（公告）日：2009-01-15

  The present invention is directed to quinazolinone compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及喹唑啉酮类化合物，这些化合物是T型钙通道的拮抗剂，可用于治疗或预防涉及T型钙通道的疾病和疾病。该发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在预防或治疗涉及T型钙通道的疾病中的用途。
• Quinazolinone T-Type Calcium Channel Antagonists
  申请人：Barrow James C.

  公开号：US20080167329A1

  公开（公告）日：2008-07-10

  The present invention is directed to quinazolinone compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及对T型钙通道具有拮抗作用的喹唑啉酮化合物，其在治疗或预防与T型钙通道有关的疾病和疾病方面具有用途。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗与T型钙通道有关的疾病方面使用这些化合物和组合物。
• Higashino, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1959, vol. 79, p. 831
  作者：Higashino

  DOI：——

  日期：——
• Yamanaka, Chemical and pharmaceutical bulletin, 1959, vol. 7, p. 158,160
  作者：Yamanaka

  DOI：——

  日期：——
• QUINAZOLINONE T-TYPE CALCIUM CHANNEL ANTAGONISTS
  申请人：Merck & Co., Inc.

  公开号：EP1858520A2

  公开（公告）日：2007-11-28