1-cyclohexyl-1H-pyrrolo[3’,2’:5,6]pyrido[4,3-d]pyrimidine-2,4(3H,7H)-dione | 1423054-25-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 1-cyclohexyl-1H-pyrrolo[3’,2’:5,6]pyrido[4,3-d]pyrimidine-2,4(3H,7H)-dione
• 英文别名: 13-Cyclohexyl-5,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1,3,6,8-tetraene-10,12-dione
• CAS: 1423054-25-4
• 化学式: C₁₅H₁₆N₄O₂
• 分子量: 284.318
• InChiKey: KKRUGHFUQMEZNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  78.1
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] TRICYCLIC HETEROCYCLIC COMPOUNDS AND JAK INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES TRICYCLIQUES ET INHIBITEURS DE JAK
  申请人：NISSAN CHEMICAL IND LTD

  公开号：WO2013024895A1

  公开（公告）日：2013-02-21

  Novel tricyclic pyrimidine compounds and tricyclic pyridine compounds having JAK inhibitory activities are provided. A tricyclic heterocyclic compound represented by the formula (Ia): wherein the rings Aa and Ba, Xa, Ya, R1a, R2a, R3a, L1a, L2a, L3a and na are as defined in the description.

  本发明提供了具有JAK抑制活性的新型三环嘧啶化合物和三环吡啶化合物。其中一种三环杂环化合物的化学式为（Ia）：其中环Aa和Ba，Xa，Ya，R1a，R2a，R3a，L1a，L2a，L3a和na的定义如描述中所述。
• TRICYCLIC HETEROCYCLIC COMPOUNDS AND JAK INHIBITORS
  申请人：Hayashi Keishi

  公开号：US20140200344A1

  公开（公告）日：2014-07-17

  Novel tricyclic pyrimidine compounds and tricyclic pyridine compounds having JAK inhibitory activities are provided. A tricyclic heterocyclic compound represented by the formula (I a ): wherein the rings A a and B a , X a , Y a , R 1a , R 2a , R 3a , L 1a L 2a , L 3a and n a are as defined in the description.

  本发明提供了具有JAK抑制活性的新型三环嘧啶化合物和三环吡啶化合物。其中，化合物的式(Ia)表示为：其中，环Aa和Ba，Xa，Ya，R1a，R2a，R3a，L1aL2a，L3a和na的定义详见说明。
• TRICYCLIC PYRROLOPYRIDINE COMPOUND, AND JAK INHIBITOR
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20150368245A1

  公开（公告）日：2015-12-24

  To provide a novel tricyclic pyrrolopyridine compound having a JAK inhibitory activity and useful for prevention, treatment and/or improvement of particularly autoimmune diseases, inflammatory diseases and allergic diseases. A novel tricyclic pyrrolopyridine compound represented by the formula (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof: wherein the respective substituents are defined in detail in the specification, and R 1 is a C 1-6 alkyl group or the like, R 2 is a hydrogen atom or the like, R 3 is a hydrogen atom or the like, the ring A is C 3-11 cycloalkane or the like, L 1 is a C 1-6 alkylene group or the like, and R 4 is NR a R b or the like.

  提供一种新型三环吡咯吡啶化合物，具有JAK抑制活性，可用于预防、治疗和/或改善特别是自身免疫性疾病、炎症性疾病和过敏性疾病。该化合物由式(I)、化合物的互变异构体或药学上可接受的盐或其溶剂化物表示：其中各取代基在规范中详细定义，R1为C1-6烷基或类似物，R2为氢原子或类似物，R3为氢原子或类似物，环A为C3-11环烷基或类似物，L1为C1-6烷基或类似物，R4为NRaRb或类似物。
• US9216999B2
  申请人：——

  公开号：US9216999B2

  公开（公告）日：2015-12-22
• US9475813B2
  申请人：——

  公开号：US9475813B2

  公开（公告）日：2016-10-25