7-Aethyl-2-methylcoumaran | 58621-44-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: 7-Aethyl-2-methylcoumaran
• 英文别名: 7-Ethyl-2-methyl-2,3-dihydro-1-benzofuran
• CAS: 58621-44-6
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: LLWAXIXIPGLBEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• NEMATOCIDAL SULFONAMIDES
  申请人：Lahm George Philip

  公开号：US20120114624A1

  公开（公告）日：2012-05-10

  Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein Z is O or S; and R 1 , R 2 , R 3 , Q and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling a parasitic nematode comprising contacting the parasitic nematode or its environment with a biologically effective amount of a compound or a composition of the invention.

  本发明涉及一种化合物，其分子式为1，N-氧化物及其盐，其中Z为O或S; R1，R2，R3，Q和n如所述。本发明还涉及含有该化合物的组合物以及使用该化合物或该组合物与寄生线虫或其环境接触以控制寄生线虫的方法。
• [EN] GRK2 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE GRK2 ET LEURS UTILISATIONS
  申请人：CYGNAL THERAPEUTICS INC

  公开号：WO2021242844A1

  公开（公告）日：2021-12-02

  The present disclosure features useful methods to treat cancer, e.g., in a subject in need thereof. The methods described herein are useful in the treatment of disorders associated with GRK2 expression, e.g., cancer or cardiovascular disease. The present disclosure also features compounds (e.g., GRK2 inhibitors), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof.