4-(1-methyl-1H-pyrrol-2-yl)-1-(2-(piperidin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidine | 1610340-03-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 4-(1-methyl-1H-pyrrol-2-yl)-1-(2-(piperidin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidine
• 英文别名: 4-(1-Methylpyrrol-2-yl)-1-(2-piperidin-1-ylethyl)pyrazolo[3,4-d]pyrimidine
• CAS: 1610340-03-8
• 化学式: C₁₇H₂₂N₆
• 分子量: 310.402
• InChiKey: PYTMSMXFBBOXGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINE COMPOUNDS, THEIR PREPARATION AND USE AS|SIGMA RECEPTORS LIGANDS<br/>[FR] COMPOSÉS DE PYRAZOLO[3,4-D]PYRIMIDINE SUBSTITUÉS, LEUR PRÉPARATION ET LEUR UTILISATION COMME LIGANDS DES RÉCEPTEURS SIGMA
  申请人：ESTEVE LABOR DR

  公开号：WO2014076170A1

  公开（公告）日：2014-05-22

  The present invention relates to new substituted pyrazolo[3,4- d]pyrimidine compounds of general formula (I) having a great affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them and to their use as medicaments for the treatment of i.a. pain. n is selected from 1, 2, 3 or 4; R1 represents a carbon-linked optionally substituted aryl or heteroaryl radical; R2 and R3 independently represent a hydrogen atom, an optionally substituted aliphatic, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl radical, or R2 and R3 together with the bridging nitrogen form an optionally substituted heterocycloalkyl or heteroaryl radical.

  本发明涉及具有通式(I)的新取代吡唑并[3,4-d]嘧啶化合物，其对sigma受体，特别是sigma-1受体具有高亲和力，以及涉及其制备方法、包含它们的组合物以及它们作为药物用于治疗疼痛等疾病的用途。n选自1、2、3或4；R1代表碳连接的可选取代的芳基或杂芳基基团；R2和R3独立地代表氢原子、可选取代的脂肪族、环烷基、环烷基烷基、芳基、芳基烷基、杂芳基、杂芳基烷基、杂环基或杂环基烷基基团，或者R2和R3与桥接的氮原子一起形成可选取代的杂环烷基或杂芳基基团。
• Substituted pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma receptors ligands
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP2733143A1

  公开（公告）日：2014-05-21

  The present invention relates to new substituted pyrazolo [3,4-d]pyrimidine compounds of general formula (I), having a great affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments for the treatment of i.a. pain. n is selected from 1, 2, 3 or 4; R1 represents a carbon-linked optionally substituted aryl or heteroaryl radical; R2 and R3 independently represent a hydrogen atom, an optionally substituted aliphatic, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl radical, or R2 and R3 together with the bridging nitrogen form an optionally substituted heterocyclyl or heteroaryl radical.

  本发明涉及一种新的取代吡唑[3,4-d]嘧啶化合物，其通式为(I)，具有对σ受体，特别是σ-1受体的高亲和力，以及其制备方法，包括它们的组成物，以及它们作为治疗药物的用途。其中n选自1、2、3或4；R1代表一个碳链连接的可选择取代的芳基或杂环芳基基团；R2和R3独立地代表氢原子，一个可选择取代的脂肪烃基、环烷烃基、环烷基烷基、芳基、芳基烷基、杂环芳基、杂环芳基烷基、杂环基或杂环基烷基基团，或者R2和R3与桥接氮一起形成一个可选择取代的杂环基或杂环芳基基团。
• SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS, THEIR PREPARATION AND USE AS SIGMA RECEPTORS LIGANDS
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：US20150315192A1

  公开（公告）日：2015-11-05

  The present invention relates to new substituted pyrazolo[3,4-d]pyrimidine compounds, having a great affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.

  本发明涉及新的取代的吡唑并[3,4-d]嘧啶化合物，具有对sigma受体，特别是sigma-1受体的高亲和力，以及其制备过程，包含它们的组合物和它们作为药物的用途。
• SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINE COMPOUNDS, THEIR PREPARATION AND USE AS SIGMA RECEPTORS LIGANDS
  申请人：Laboratorios del Dr. Esteve, S.A.

  公开号：EP2920174A1

  公开（公告）日：2015-09-23
• US9278974B2
  申请人：——

  公开号：US9278974B2

  公开（公告）日：2016-03-08