3-[3-(3-Aminopropoxy)-5-[8-[3,5-bis(3-aminopropoxy)phenyl]dibenzothiophen-2-yl]phenoxy]propan-1-amine | 1613643-70-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 3-[3-(3-Aminopropoxy)-5-[8-[3,5-bis(3-aminopropoxy)phenyl]dibenzothiophen-2-yl]phenoxy]propan-1-amine
• CAS: 1613643-70-1
• 化学式: C₃₆H₄₄N₄O₄S
• 分子量: 628.836
• InChiKey: KHJPRAQXKVEAPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  45
• 可旋转键数：
  18
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  169
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• Polymeric Compounds And Methods Of Making And Using The Same
  申请人：Fan Xiaodong

  公开号：US20140308317A1

  公开（公告）日：2014-10-16

  The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; killing or inhibiting the growth of a Plasmodium species; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.

  本公开提供化合物或其药学上可接受的盐，用于抑制微生物的生长；治疗患有微生物感染，疟疾，口腔炎，眼部感染，耳部感染，癌症或结核分枝杆菌感染的哺乳动物；杀死或抑制疟原虫的生长；抑制结核分枝杆菌的生长；调节哺乳动物的免疫反应；或拮抗非分散肝素，低分子量肝素或肝素/低分子量肝素衍生物。
• [EN] POLYCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME<br/>[FR] COMPOSÉS POLYCYCLIQUES ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：CELLCEUTIX CORP

  公开号：WO2014093225A2

  公开（公告）日：2014-06-19

  The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; killing or inhibiting the growth of a Plasmodium species; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.