7-{[4-(3,4-dichlorobenzyl)homopiperazino-(1)]propyl}-theophylline | 757139-47-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 7-{[4-(3,4-dichlorobenzyl)homopiperazino-(1)]propyl}-theophylline
• 英文别名: 7-[3-[4-[(3,4-Dichlorophenyl)methyl]-1,4-diazepan-1-yl]propyl]-1,3-dimethylpurine-2,6-dione
• CAS: 757139-47-2
• 化学式: C₂₂H₂₈Cl₂N₆O₂
• 分子量: 479.409
• InChiKey: ORXZQPMNLFVKLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  64.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Theophylline derivatives, a process for the preparation of the same and a therapeutical composition
  申请人：Eisai Co., Ltd.

  公开号：EP0023350A1

  公开（公告）日：1981-02-04

  Derivatives of the theophylline substituted at the 7-position whith various substituents containing a homopiperazine nucieus. The compounds can be prepared reacting theophylline or reactive intermediate containing same with a homopiperazine compound. The compounds in the form of a therapeutical composition exhibiting antihistaminic activity and vasodilating activity.

  茶碱的衍生物在 7 位被含有均哌嗪的各种取代基取代。这些化合物可通过茶碱或含有茶碱的反应中间体与均哌嗪化合物反应制备。这些化合物具有抗组胺活性和血管扩张活性。
• NEUROGENESIS BY MODULATING ANGIOTENSIN
  申请人：BARLOW Carrolee

  公开号：US20110269717A1

  公开（公告）日：2011-11-03

  The instant invention describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The invention includes compositions and methods based on modulating angiotensin activity to stimulate or activate the formation of new nerve cells.
• US4599414A
  申请人：——

  公开号：US4599414A

  公开（公告）日：1986-07-08