4-Amino-2,3,5,6,7,8-hexahydro-chinazolin-2-on | 1127-87-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-Amino-2,3,5,6,7,8-hexahydro-chinazolin-2-on
• 英文别名: 4-amino-5,6,7,8-tetrahydro-1H-quinazolin-2-one
• CAS: 1127-87-3
• 化学式: C₈H₁₁N₃O
• 分子量: 165.195
• InChiKey: HHLFUIZKSPWSPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-Cyan-cyclohex-1-en-2-yl-harnstoff 在 ammonium hydroxide 作用下， 反应 0.08h， 以100%的产率得到4-Amino-2,3,5,6,7,8-hexahydro-chinazolin-2-on
  参考文献：
  名称：

  Bischoff, Christian; Schroeder, Edith, Journal fur praktische Chemie (Leipzig 1954), 1983, vol. 325, # 1, p. 88 - 94

  摘要：

  DOI：

文献信息

• MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH
  申请人：SENOMYX, INC.

  公开号：US20140235623A1

  公开（公告）日：2014-08-21

  The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.

  本发明涉及识别化学感受受体及其配体的修饰剂的方法，例如通过确定测试实体是否适合与化学感受受体的捕蝇夹结构域内的一个或多个相互作用位点相互作用来确定。本发明还包括能够调节化学感受受体及其配体的修饰剂。本发明还包括具有公式(I)及其亚属和特定化合物的化学感受受体及其配体的修饰剂。此外，本发明还包括含有化学感受受体及其配体的修饰剂的可食用组合物及使用化学感受受体及其配体的修饰剂增强可食用组合物的甜味或治疗与化学感受受体相关的疾病的方法。此外，本发明还包括制备化学感受受体及其配体的修饰剂的方法。
• Modulation of chemosensory receptors and ligands associated
  申请人：Senomyx, Inc.

  公开号：EP2568287A2

  公开（公告）日：2013-03-13

  The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention includes processes for preparing the modifiers of chemosensory receptors and their ligands.

  本发明包括鉴定化感受体及其配体的修饰剂的方法，例如，通过确定试验实体是否适合与化感受体金星捕蝇草结构域内的一个或多个相互作用位点相互作用，以及能够修饰化感受体及其配体的修饰剂。本发明还包括具有式（I）、其亚属和特定化合物的化感受体及其配体的调节剂。此外，本发明还包括包含化感受体修饰剂及其配体的可食用组合物，以及使用化感受体修饰剂及其配体提高可食用组合物甜味或治疗与化感受体相关疾病的方法。此外，本发明还包括制备化感受体修饰剂及其配体的工艺。
• BISCHOFF, C.;SCHROEDER, E., J. PRAKT. CHEM., 1983, 325, N 1, 88-94
  作者：BISCHOFF, C.、SCHROEDER, E.

  DOI：——

  日期：——
• SWEETENER COMPOSITION
  申请人：Senomyx, Inc.

  公开号：US20180086751A1

  公开（公告）日：2018-03-29

  Formulations comprising one or more sweetener and one or more flavor modifying compound are provided herein, wherein the formulation is provided for use in ingestible products, such as food or beverage products or pharmaceutical, or for use in non-comestible products, such as cosmetic or hygienic products. The formulations include combinations of any one or more sweetener in combination with any one or more flavor modifying compound described or referenced herein.
• US8633186B2
  申请人：——

  公开号：US8633186B2

  公开（公告）日：2014-01-21