Fmoc-Arg(Me)HisLys(Ac)Lys(Ac)-aminoluciferin | 1364408-74-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Fmoc-Arg(Me)HisLys(Ac)Lys(Ac)-aminoluciferin
• 英文别名: (4S)-2-[6-[[(2S)-6-acetamido-2-[[(2S)-6-acetamido-2-[[(2S)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(N'-methylcarbamimidoyl)amino]pentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]hexanoyl]amino]-1,3-benzothiazol-2-yl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid
• CAS: 1364408-74-1
• 化学式: C₅₅H₆₈N₁₄O₁₀S₂
• 分子量: 1149.36
• InChiKey: QSNRWILYKDDAKZ-MDZIXCKASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  81
• 可旋转键数：
  31
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  408
• 氢给体数：
  11
• 氢受体数：
  16

文献信息

• METHODS FOR ASSAYING ENZYME ACTIVITIES
  申请人：Kirkland Thomas

  公开号：US20120064554A1

  公开（公告）日：2012-03-15

  The present invention provides compounds and methods for assaying activities of enzymes such as histone deacetylases and histone acetyltransferases. In some embodiments, the methods may be performed in one step. The compounds described herein features peptide-based compounds having at least one blocked lysine or arginine residue which are coupled to reporter moieties. The methods described herein involve reacting a compound described herein with an enzyme, such as a histone deacetylase enzyme or a histone acetyltransferase enzyme, and an endopeptidase that recognizes basic amino acids to release the reporter moiety which may be subsequently detected.

  本发明提供了化合物和方法，用于检测酶活性，例如组蛋白去乙酰化酶和组蛋白乙酰转移酶的活性。在某些实施例中，该方法可以在一步中完成。所述化合物具有至少一个被阻断的赖氨酸或精氨酸残基的肽基化合物，与报告基团耦合。所述方法涉及将所述化合物与酶反应，例如组蛋白去乙酰化酶酶或组蛋白乙酰转移酶酶，以及识别碱性氨基酸的内肽酶来释放报告基团，随后可以检测到。
• US8632992B2
  申请人：——

  公开号：US8632992B2

  公开（公告）日：2014-01-21
• US8962266B2
  申请人：——

  公开号：US8962266B2

  公开（公告）日：2015-02-24
• [EN] METHODS FOR ASSAYING ENZYME ACTIVITIES<br/>[FR] PROCÉDÉS DE DOSAGE DES ACTIVITÉS ENZYMATIQUES
  申请人：PROMEGA CORP

  公开号：WO2012033993A2

  公开（公告）日：2012-03-15

  The present invention provides compounds and methods for assaying activities of enzymes such as histone deacetylases and histone acetyltransferases. In some embodiments, the methods may be performed in one step. The compounds described herein features peptide-based compounds having at least one blocked lysine or arginine residue which are coupled to reporter moieties. The methods described herein involve reacting a compound described herein with an enzyme, such as a histone deacetylase enzyme or a histone acetyltransferase enzyme, and an endopeptidase that recognizes basic amino acids to release the reporter moiety which may be subsequently detected.