[Co(2-acetylpyridine 4N-(2-pyridyl)thiosemicarbazone)Cl2] | 1195047-61-0

• 英文名称: [Co(2-acetylpyridine 4N-(2-pyridyl)thiosemicarbazone)Cl2]
• CAS: 1195047-61-0
• 化学式: C₁₃H₁₃Cl₂CoN₅S
• 分子量: 401.245
• InChiKey: ORHIAVVUQSKDBG-IAHIQKNASA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  (E)-N-(pyridin-2-yl)-2-(1-(pyridin-2-yl)ethylidene)hydrazine-1-carbothioamide 、 cobalt(II) chloride 以 乙醇 为溶剂， 生成 [Co(2-acetylpyridine 4N-(2-pyridyl)thiosemicarbazone)Cl2]
  参考文献：
  名称：

  Mn(II), Co(II), Zn(II), Fe(III) and U (VI) complexes of 2-acetylpyridine 4N-(2-pyridyl) thiosemicarbazone (HAPT); structural, spectroscopic and biological studies

  摘要：

  The present work carried out a study on transition metal ion complexes which have been synthesized from 2-acetylpyridine N-4-(2-pyridyl) thiosemicarbazone (HAPT) 1. These complexes namely [Zn(HAPT)Cl-2] 2, [Mn (HAPT)Cl-2] 3, [Co (HAPT)Cl-2] 4, [Fe(APT)Cl-2(H2O)] 5 and [UO2(HAPT)(OAc)(2)] 6, were characterized by elemental analysis, spectral (IR, H-1 NMR and UV-vis) and magnetic moment measurements. Thermal properties and decomposition kinetics of all compounds are investigated. The interpretation, mathematical analysis and evaluation of kinetic parameters (E, A, Delta H, Delta S and Delta G) of all thermal decomposition stages have been evaluated using Coats-Redfern equation. The biochemical studies showed that, complexes 3 and 6 have powerful and complete degradation effect on the both DNA and protein. The SOD-like activity exhibited that complex 3 has a strong antioxidative properties. The antibacterial screening demonstrated that, the free ligand (HAPT), complexes 2, 3 and 6 have the maximum and broad activities against Gram-positive and Gram-negative bacterial strains. (C) 2009 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2009.07.042