3-(p-hydroxyphenyl)asym-triazine | 111336-64-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-(p-hydroxyphenyl)asym-triazine
• 英文别名: 4-(1,2,4-Triazin-3-yl)phenol
• CAS: 111336-64-2
• 化学式: C₉H₇N₃O
• 分子量: 173.174
• InChiKey: ZCDDPZCZQYPGOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,3-二羟基-1,4-二氧杂环己烷 、 p-hydroxybenzamidrazone hydrochloride 在 三乙胺 作用下， 以 乙醇 为溶剂， 以66%的产率得到3-(p-hydroxyphenyl)asym-triazine
  参考文献：
  名称：

  Electronic spectra of asym-triazinyl groups

  摘要：

  DOI：

  10.1007/bf00663866

文献信息

• Compounds, Compositions and Methods Comprising Triazine Derivatives
  申请人：Russell Michael Geoffrey Neil

  公开号：US20090264433A1

  公开（公告）日：2009-10-22

  The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Table 1 or encompassed by formulas I-II) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及治疗动物疾病的组合物和方法，该疾病对通过向需要的哺乳动物施用本文中定义的化合物的有效量（包括表1中列出的那些化合物或由公式I-II包围的化合物）或其组合物进行抑制功能性囊性纤维化跨膜传导调节器（CFTR）多肽而产生反应，从而治疗该疾病。本发明特别涉及治疗腹泻和多囊性肾病的方法。
• Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives
  申请人：Doyle Kevin James

  公开号：US20090318429A1

  公开（公告）日：2009-12-24

  The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-14 or encompassed by formulas I-XII) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及用于治疗动物患病的组合物和方法，该疾病对通过向需要的哺乳动物投予本文所定义的化合物的有效量（包括表1-14中列出的那些化合物或被I-XII公式所包含的化合物）或其组合物来抑制功能性囊性纤维化跨膜传导调节蛋白（CFTR）多肽作出反应，从而治疗该疾病。本发明特别涉及一种治疗腹泻和多囊性肾病的方法。