N-(9-fluorenylmethoxycarbonyl)-N-[2-(methylamino)ethyl]amine hydrochloride | 229028-44-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: N-(9-fluorenylmethoxycarbonyl)-N-[2-(methylamino)ethyl]amine hydrochloride
• 英文别名: N-Fmoc-2-(methylamino)ethylamine hydrochloride；N1-Fmoc-N2-methyl-1,2-ethandiamine HCl；9H-fluoren-9-ylmethyl N-[2-(methylamino)ethyl]carbamate;hydrochloride
• CAS: 229028-44-8
• 化学式: C₁₈H₂₀N₂O₂*ClH
• 分子量: 332.83
• InChiKey: VAAZWHDCZUGTFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.17
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  50.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl 4-(2-formylethyl)benzylcarbamate 、 N-(9-fluorenylmethoxycarbonyl)-N-[2-(methylamino)ethyl]amine hydrochloride 在 三乙酰氧基硼氢化钠 作用下， 生成 N-(9-fluorenylmethoxycarbonyl)-N-[2-[N-[3-[4-(N-tert-butoxycarbonylaminomethyl)phenyl]propyl]-N-methylamino]ethyl]amine
  参考文献：
  名称：

  NOVEL AMINE DERIVATIVE HAVING HUMAN BETA-TRYPTASE INHIBITORY ACTIVITY AND DRUGS CONTAINING THE SAME

  摘要：

  本发明旨在提供一种新型低分子量胺衍生物，该衍生物被很好地吸收，毒性低，并且具有极高选择性的优异人类β-色氨酸蛋白酶抑制活性，其药学上可接受的盐，以及含有该衍生物作为活性成分的药物。本发明的药物可作为一种预防/治疗剂，用于被认为是由β-色氨酸蛋白酶引起的危机和发展的疾病，例如呼吸道疾病、过敏性疾病、炎症性肠病、皮肤过度增生疾病、血管水肿和类风湿性关节炎。

  公开号：

  EP1445250A1

文献信息

• CROSSLINKING REAGENTS, METHODS, AND COMPOSITIONS FOR STUDYING PROTEIN-PROTEIN INTERACTIONS
  申请人：Huang Yumei

  公开号：US20120322978A1

  公开（公告）日：2012-12-20

  The invention provides reagents, methods, and compositions for studying protein-protein interactions. The inventive system and methods allow the analysis of protein-protein interactions in vivo and in vitro. Advantages offered by various embodiments of the inventive system and methods compared to existing photocrosslinking approaches include, for example, (i) novel reversible crosslinking reagents that allow easy isolation, purification, and enrichment of the crosslinked products; (ii) trifluoromethyl phenyldiazirine- or perfluorinated phenylazide-based photocrosslinking reagents that provide high specific labeling, no side product, and higher photocrosslinking efficiency; (iii) versatile spacer groups that allow systematic contact site mapping; (iv) novel methods for isolating, purifying, and detecting crosslinked products based on the reversible-link chemistry; and (v) the ability to study the interaction sites in vitro, in situ, or in vivo.

  该发明提供了用于研究蛋白质-蛋白质相互作用的试剂、方法和组合物。这一创新系统和方法允许在体内和体外分析蛋白质-蛋白质相互作用。与现有的光交联方法相比，该创新系统和方法的各种实施例提供的优势包括：（i）新型可逆交联试剂，可方便地分离、纯化和富集交联产物；（ii）三氟甲基苯基重氮基或全氟苯基偶氮基光交联试剂提供高特异标记、无副产物和更高的光交联效率；（iii）多功能的间隔基团，可进行系统的接触位点映射；（iv）基于可逆链接化学的新方法用于分离、纯化和检测交联产物；以及（v）能够在体外、原位或体内研究相互作用位点。
• Methods, Mixtures, Kits and Compositions Pertaining to Analyte Determination
  申请人：Pillai K. Sasi

  公开号：US20070218560A1

  公开（公告）日：2007-09-20

  This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination by mass spectrometry.

  本发明涉及通过质谱法确定分析物的方法、混合物、试剂盒和组合物。
• METHODS, MIXTURES, KITS AND COMPOSITIONS PERTAINING TO ANALYTE DETERMINATION
  申请人：Applera Corporation

  公开号：EP1984726A2

  公开（公告）日：2008-10-29
• Novel amine derivative having human beta-tryptase inhibitory activity and drugs containing the same
  申请人：Kato Yutaka

  公开号：US20050043304A1

  公开（公告）日：2005-02-24

  It is intended to provide a novel low-molecular weight amine derivative, that is absorbed well, has low toxicity, and has an excellent human β-tryptase inhibitory activity with extremely high selectivity, a pharmaceutically acceptable salt thereof, and a medicine containing the same as an active ingredient. The medicine of the present invention is efficacious as a prophylactic/therapeutic agent for diseases in the crisis and evolution of which are considered to be attributed to β-tryptase, for example, respiratory diseases, allergic diseases, inflammatory bowel diseases, hyperprolliferative skin diseases, vascular edema and rheumatoid arthritis.
• US8975404B2
  申请人：——

  公开号：US8975404B2

  公开（公告）日：2015-03-10