b-氨基-2-萘丙醇 | 148452-31-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: b-氨基-2-萘丙醇
• 英文名称: 3-(β-Naphthyl)-2-amino-propanol
• 英文别名: 2-amino-3-(2-naphthyl)propan-1-ol；2-Amino-3-(naphthalen-2-yl)propan-1-ol；2-amino-3-naphthalen-2-ylpropan-1-ol
• CAS: 148452-31-7
• 化学式: C₁₃H₁₅NO
• 分子量: 201.268
• InChiKey: LZJYDHODVGJYLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  b-氨基-2-萘丙醇 、 氯乙酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以72%的产率得到2-chloro-N-[2-hydroxy-1-(2-naphthylmethyl)ethyl]acetamide
  参考文献：
  名称：

  4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase

  摘要：

  4-(1,3-Thiazol-2-yl)morpholine derivatives have been identified as potent and selective inhibitors of phosphoinositide 3-kinase. The SAR data of selected examples are presented and the in vivo pro. ling of compound 18 is shown to demonstrate the utility of this class of compounds in xenograft models of tumor growth. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.076
• 作为产物：
  描述：

  1-(naphthalen-2-yl)propan-2-one oxime 生成 b-氨基-2-萘丙醇
  参考文献：
  名称：

  氢化铝锂还原肟形成氮丙啶

  摘要：

  通过LAH还原肟形成的叠氮基已扩展为多种类型，例如和，其结果对于该反应的一般化是令人满意的。

  DOI：

  10.1016/s0040-4020(01)92001-0

文献信息

• Arylmethylene substituted N-acyl-beta-amino alcohols
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP2018859A1

  公开（公告）日：2009-01-28

  The present invention relates to arylmethylene substituted N-Acyl-β-amino alcohols of the formula I in which Y is selected from the aryl or heteroaryl groups: and R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及式I的芳基亚甲基取代的N-酰基-β-氨基醇 其中 Y 从芳基或杂芳基中选择: 和 R1、R2、R3、R4、R5、Q、X和W的含义如描述中所定义。 根据本发明的化合物是有效的FSH拮抗剂，例如可用于男性或女性的生育控制，或用于骨质疏松症的预防和/或治疗。
• Arylmethylene Substituted N-Acyl-Beta-Amino Alcohols
  申请人：WORTMANN Lars

  公开号：US20090082372A1

  公开（公告）日：2009-03-26

  The present invention relates to arylmethylene substituted N-Acyl-β-amino alcohols of the formula I in which Y is selected from the aryl or heteroaryl groups: and R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及公式I的芳基亚甲基取代的N-酰基-β-氨基醇化合物，其中Y选自芳基或杂芳基基团：R1，R2，R3，R4，R5，Q，X和W的含义如描述中所定义。本发明的化合物是有效的FSH拮抗剂，例如可用于男性或女性的生育控制，或用于骨质疏松症的预防和/或治疗。
• Fused Thiazole Derivatives as Kinase Inhibitors
  申请人：Alexander Rikki Peter

  公开号：US20080306060A1

  公开（公告）日：2008-12-11

  A series of 5,6-dihydro-1,3-benzothiazol-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PD kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

  一系列取代在2位位置具有可选取代的morpholin-4-yl基团的5,6-二氢-1,3-苯并噻唑-7(4H)-酮衍生物及其类似物，是选择性PD激酶酶抑制剂，在医学上具有益处，例如在治疗炎症、自身免疫、心血管、神经退行性、代谢、肿瘤、疼痛或眼科疾病方面。
• Amphiphilic block copolymer, preparation method thereof and nanomicelle drug-loading system
  申请人：Zhang Fuyao

  公开号：US11225551B2

  公开（公告）日：2022-01-18

  The present invention relates to an amphiphilic block copolymer represented by formula I, a preparation method thereof, and a nanomicelle drug delivery system formed from the copolymer and a poorly soluble drug. The amphiphilic block copolymer includes a hydrophilic chain segment, a hydrophobic chain segment, and a linker for linking the hydrophilic chain segment to the hydrophobic chain segment. The linker contains an unsaturated structure, which can enhance the interaction between the poorly soluble drug and the copolymer to improve the drug loading ability and stability of the nanomicelle. The invention also relates to a nanomicelle drug-loading system, a preparation method thereof, and the use of the nanomicelle drug-loading system for preparing medicines for treating tumors, inflammation, diabetes, central nervous system diseases, cardiovascular diseases, and psychological disorders.

  本发明涉及一种由式 I 表示的两亲嵌段共聚物、其制备方法以及由该共聚物和一种难溶性药物形成的纳米胶束给药系统。两亲嵌段共聚物包括亲水链段、疏水链段和用于连接亲水链段和疏水链段的连接剂。链接剂含有不饱和结构，可增强溶解性差的药物与共聚物之间的相互作用，从而提高纳米胶束的载药能力和稳定性。本发明还涉及一种纳米胶束载药系统及其制备方法，以及该纳米胶束载药系统用于制备治疗肿瘤、炎症、糖尿病、中枢神经系统疾病、心血管疾病和心理障碍的药物。
• PROCEDE DE PREPARATION IN SITU DE COMPOSES CHIRAUX DERIVES DE COMPLEXES D'OXAZABOROLIDINE-BORANE UTILES DANS LES REACTIONS DE REDUCTION ASYMETRIQUE
  申请人：PPG-Sipsy

  公开号：EP1673375A2

  公开（公告）日：2006-06-28