3-(1H-Indol-3-yl)-N-(4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidine-2-ylmethyl)-N-thiophene-2-ylmethyl-propionamide | 1418131-51-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 3-(1H-Indol-3-yl)-N-(4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidine-2-ylmethyl)-N-thiophene-2-ylmethyl-propionamide
• 英文别名: 3-(1H-Indol-3-yl)-N-(4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-ylmethyl)-N-thiophen-2-ylmethyl-propionamide；3-(1H-indol-3-yl)-N-(4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-yl-methyl)-N-thiophen-2-ylmethyl-propanamide；3-(1H-Indol-3-yl)-N-(4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-ylmethyl)-N-thiophen-2-ylmethyl-propionamid；3-(1H-indol-3-yl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamide
• CAS: 1418131-51-7
• 化学式: C₂₄H₂₄N₄O₃S
• 分子量: 448.546
• InChiKey: SXLDHGPJYSGHMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] 4-OXO-3,5,7,8-TETRAHYDRO-4H-PYRANO {4,3-D} PYRMINIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS<br/>[FR] COMPOSÉS DE 4-OXO-3,5,7,8-TÉTRAHYDRO-4H-PYRANO{4,3-D}PYRIMINIDINYLE UTILISABLES À TITRE D'INHIBITEURS DE TANKYRASES
  申请人：NOVARTIS AG

  公开号：WO2013010092A1

  公开（公告）日：2013-01-17

  The present invention provides for compounds of formula (I) wherein R1 and R2 are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.

  本发明提供了以下式（I）中R1和R2被定义的化合物。本发明还提供了含有式（I）化合物的药物组合物和配方，以及将这些化合物用作坦基酶抑制剂以及用于治疗Wnt信号和坦基酶1和2信号相关疾病的用途，包括但不限于癌症。
• 4-OXO-3,5,7,8-TETRAHYDRO-4H-PYRANO[4,3-D]PYRMINIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS
  申请人：Novartis AG

  公开号：US20150210709A1

  公开（公告）日：2015-07-30

  The present invention provides for compounds of formula (I) wherein R 1 and R 2 are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.

  本发明提供了公式（I）中R1和R2被定义的化合物。本发明还提供了包含公式（I）化合物的制药组合物和组合物，以及将这些化合物用作坦克酶抑制剂和治疗Wnt信号和坦克酶1和2信号相关疾病的用途，其中包括但不限于癌症。
• 4-OXO-3,5,7,8-TETRAHYDRO-4H-PYRANO {4,3-D} PYRMINIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS
  申请人：Novartis AG

  公开号：EP2731951A1

  公开（公告）日：2014-05-21
• US9227982B2
  申请人：——

  公开号：US9227982B2

  公开（公告）日：2016-01-05