3-{4-morpholin-4-yl-7-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-5H-pyrrolo[3,2-d]pyrimidin-2-yl}phenol | 1155811-14-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 3-{4-morpholin-4-yl-7-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-5H-pyrrolo[3,2-d]pyrimidin-2-yl}phenol
• 英文别名: 3-[4-morpholin-4-yl-7-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-5H-pyrrolo[3,2-d]pyrimidin-2-yl]phenol
• CAS: 1155811-14-5
• 化学式: C₂₇H₃₀N₆O₂
• 分子量: 470.574
• InChiKey: GYXBXBDOHQSHNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  90.4
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS
  申请人：CHEN Zecheng

  公开号：US20090149458A1

  公开（公告）日：2009-06-11

  A pyrrolo[3,2-d]pyrimidine compound, such as a compound of the formula (I): or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.

  一种吡咯并[3,2-d]嘧啶化合物，例如具有以下式（I）的化合物：或其药用可接受的盐，其中构成变量如本文所定义，包括所述化合物的组合物，以及制备和使用所述化合物的方法。
• [EN] PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND MTOR KINASE INHIBITORS<br/>[FR] COMPOSÉS DE PYRROLO[3,2-D]PYRIMIDINE ET LEUR UTILISATION COMME INHIBITEURS DE LA PI3 KINASE ET DE LA MTOR KINASE
  申请人：WYETH CORP

  公开号：WO2009070524A1

  公开（公告）日：2009-06-04

  A pyrrolo[3,2-d]pyrimidine compound, such as a compound of the formula (I); or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds, useful for treating PI3K-related diseases.