2-(3-chloro-4-methyl-phenyl)-3-(2-hydroxy-phenylsulfanyl)-5,6-dimethoxy-2,3-dihydro-isoindol-1-on | 1221160-78-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(3-chloro-4-methyl-phenyl)-3-(2-hydroxy-phenylsulfanyl)-5,6-dimethoxy-2,3-dihydro-isoindol-1-on
• 英文别名: 2-(3-chloro-4-methylphenyl)-3-(2-hydroxyphenyl)sulfanyl-5,6-dimethoxy-3H-isoindol-1-one
• CAS: 1221160-78-6
• 化学式: C₂₃H₂₀ClNO₄S
• 分子量: 441.935
• InChiKey: UBMSDRYLFMYNED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  84.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-羟基苯硫酚 、 以 氯仿 为溶剂， 反应 6.0h， 以0.601 g的产率得到2-(3-chloro-4-methyl-phenyl)-3-(2-hydroxy-phenylsulfanyl)-5,6-dimethoxy-2,3-dihydro-isoindol-1-on
  参考文献：
  名称：

  Mild and efficient syntheses of diverse isoindolinones from ortho-phthaldehydic acid methylthiomethyl ester

  摘要：

  A mild and efficient method for the synthesis of diverse isoindolinones from o-phthaldehydic acid methylthiomethyl ester and aliphatic/aromatic amines has been developed A number of nucleophiles Including a hydride ion were Successfully added to the intermediate Schiff's base providing iso-indolinones. with or Without substitution at 3-position Conditions have also been developed for amines with an integrated nucleophilic group to react in a diverse fashion either to give isoindolinones or tricyclic gamma-lactams as single diastereoisomers in very good yield (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2010.01.070

文献信息

• Mild and efficient syntheses of diverse isoindolinones from ortho-phthaldehydic acid methylthiomethyl ester
  作者：Usha Ghosh、Rituparna Bhattacharyya、Ashish Keche

  DOI：10.1016/j.tet.2010.01.070

  日期：2010.3

  A mild and efficient method for the synthesis of diverse isoindolinones from o-phthaldehydic acid methylthiomethyl ester and aliphatic/aromatic amines has been developed A number of nucleophiles Including a hydride ion were Successfully added to the intermediate Schiff's base providing iso-indolinones. with or Without substitution at 3-position Conditions have also been developed for amines with an integrated nucleophilic group to react in a diverse fashion either to give isoindolinones or tricyclic gamma-lactams as single diastereoisomers in very good yield (C) 2010 Elsevier Ltd All rights reserved