10-chloro-14-ethyl-3,5,7,14,17,22,27-heptaazatetracyclo[19.3.1.1~2,6~.1~8,12~]heptacosa-1(25),2(27),3,5,8(26),9,11,21,23-nonaen-16-one | 919085-22-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: 10-chloro-14-ethyl-3,5,7,14,17,22,27-heptaazatetracyclo[19.3.1.1~2,6~.1~8,12~]heptacosa-1(25),2(27),3,5,8(26),9,11,21,23-nonaen-16-one
• 英文别名: 10-Chloro-14-ethyl-3,5,7,14,17,22,27-heptazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2(27),3,5,8,10,12(26),21,23-nonaen-16-one
• CAS: 919085-22-6
• 化学式: C₂₂H₂₄ClN₇O
• 分子量: 437.932
• InChiKey: OKFUUNSOBGTDNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  31
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  95.9
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Differentiation of pluripotent stem cells
  申请人：Janssen Biotech, Inc.

  公开号：US10233421B2

  公开（公告）日：2019-03-19

  The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

  本发明涉及多能干细胞的分化方法。特别是，本发明涉及将多能干细胞分化成表达明确内胚层特征标记的细胞的方法和组合物，包括在含有足量 GDF-8 的培养基中培养多能干细胞，使多能干细胞分化成表达明确内胚层特征标记的细胞。
• Methods for making definitive endoderm using at least GDF-8
  申请人：Janssen Biotech, Inc.

  公开号：US10351820B2

  公开（公告）日：2019-07-16

  The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

  本发明涉及多能干细胞的分化方法。特别是，本发明涉及将多能干细胞分化成表达明确内胚层特征标记的细胞的方法和组合物，包括在含有足量 GDF-8 的培养基中培养多能干细胞，使多能干细胞分化成表达明确内胚层特征标记的细胞。
• Differentiation of Pluripotent Stem Cells
  申请人：Davis Janet

  公开号：US20100015711A1

  公开（公告）日：2010-01-21

  The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.
• CYCLIC ANILINO - PYRIDINOTRIAZINES
  申请人：Rombouts Frederik Jan Rita

  公开号：US20100222574A1

  公开（公告）日：2010-09-02

  The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m represents 1, n represents 1, Z represents N or C, in particular N; —X 1 — represents C 1-4 alkyl, in particular methyl; —X 2 — represents —C 1-4 alkyl- or —C 1-4 alkyl-NR 7 —, in particular propyl, -ethyl-NR 7 — or -propyl-NR 7 —; —Y— represents-NR 2 —C 1-6 alkyl-CO—NR 4 —, -Het 1 -C 1-6 alkyl-CO—NR 5 — or -Het 2 -CO—NR 6 — and wherein the —C 1-6 alkyl-linker of —NR 2 —C 1-6 alkyl-CO—NR 4 — or -Het 1 -C 1-6 alkyl-CO—NR 5 — is optionally substituted with one or where possible two or more substituents selected from hydroxy, halo and phenyl; R 1 represents hydrogen, chloro, fluoro or bromo; R 2 represents —C 1-4 alkyl-, in particular ethyl or methyl; R 7 represents hydrogen; R 8 represents hydrogen; R 4 , R 5 and R 6 represent hydrogen; Het 1 is selected from piperazinyl or piperidinyl, in particular -piperazinyl; Het 2 selected from pyrrolidinyl or piperidinyl, in particular pyrrolidinyl wherein said pyrrolidinyl is optionally substituted with hydroxy.
• DIFFERENTIATION OF PLURIPOTENT STEM CELLS
  申请人：Janssen Biotech, Inc.

  公开号：US20170183625A1

  公开（公告）日：2017-06-29

  The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.