3,4-dihydro-3-hydroxy-6,7-dimethoxy-4-oxo-1,2,3-benzotriazine | 132533-62-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并-1,2,3-三嗪类化合物
• 英文名称: 3,4-dihydro-3-hydroxy-6,7-dimethoxy-4-oxo-1,2,3-benzotriazine
• 英文别名: 3-Hydroxy-6,7-dimethoxy-1,2,3-benzotriazin-4-one
• CAS: 132533-62-1
• 化学式: C₉H₉N₃O₄
• 分子量: 223.188
• InChiKey: WSWUZAHVQYJPRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  83.7
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氨基-4,5-二甲氧基苯甲酸 生成 3,4-dihydro-3-hydroxy-6,7-dimethoxy-4-oxo-1,2,3-benzotriazine
  参考文献：
  名称：

  A Facile One-Pot Synthesis of 3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine and Derivatives

  摘要：

  本研究描述了一种直接从蒽酸一步合成 3,4-二氢-3-羟基-4-氧代-1,2,3-苯并三嗪（Dhbt-OH）及其衍生物的新方法。蚁酸和亚硫酰氯反应生成不稳定的亚磺酰胺酸酐，这些酸酐经 O-(三甲基硅烷基)羟胺处理后再重氮化，可得到相应的 Dhbt-OH 衍生物，总收率很高。

  DOI：

  10.1055/s-1990-27078

文献信息

• Catalyst comprising a nitrogen-containing heterocylic compound
  申请人：Daicel Chemical Industries, Ltd.

  公开号：EP1085015A2

  公开（公告）日：2001-03-21

  A catalyst is for use in a reaction using an oxygen-atom-containing reactant arid includes a nitrogen-containing heterocyclic compound of the following formula (1): wherein each of R1 and R2 is, identical to or different from each other, a hydrogen atom, a halogen atom, an alkyl group, a haloalkyl group, an aryl group, a cycloalkyl group, a hydroxyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group, or an acyl group, and R1 and R2 may be combined to form a double bond or to form an aromatic or non-aromatic ring with the adjacent two carbon atoms, where one or two of heterocyclic ring containing three nitrogen atoms indicated in the formula may be further formed on the R1 or R2, or on the double bond or aromatic or non-aromatic ring formed by R1 and R2; X is an oxygen atom or a hydroxyl group; and Y is a single bond, a methylene group, or a carbonyl group. This catalyst can introduce an oxygen-atom-containing group into an organic substrate under mild conditions.

  一种催化剂用于使用含氧原子的反应物的反应，包括下式(1)的含氮杂环化合物： 其中 R1 和 R2 各自是相同或不同的氢原子、卤素原子、烷基、卤代烷基、芳基、环烷基、羟基、烷氧基、羧基、烷氧羰基或酰基、且 R1 和 R2 可结合形成双键，或与相邻的两个碳原子形成芳香环或非芳香环，其中 R1 或 R2 上，或 R1 和 R2 形成的双键或芳香环或非芳香环上可进一步形成式中所示的含有三个氮原子的杂环中的一个或两个；X 是氧原子或羟基；Y 是单键、亚甲基或羰基。这种催化剂可以在温和的条件下将含氧原子的基团引入有机底物中。
• METHOD FOR PRODUCING HAIRPIN SINGLE-STRAND RNA MOLECULES
  申请人：Toray Industries, Inc.

  公开号：EP3862431A1

  公开（公告）日：2021-08-11

  The present invention relates to a method for producing a hairpin single-stranded RNA molecule capable of inhibiting expression of a target gene, comprising the step of reacting a first single-stranded oligo-RNA molecule represented by the following formula (I) with a second single-stranded oligo-RNA molecule represented by the following formula (II) in a mixed solvent comprising a buffer solution and a hydrophilic organic solvent in the presence of a dehydration condensation agent: 5'-Xc-Lx1 ... (I) and Lx2-X-Y-Ly-Yc-3' ... (II), wherein the dehydration condensation agent is selected from the group consisting of a triazine-based dehydration condensation agent, a uronium-based dehydration condensation agent comprising an N-hydroxy nitrogen-containing aromatic ring structure, a carbodiimide-based dehydration condensation agent, a 2-halopyridinium-based dehydration condensation agent, and a formamidinium-based dehydration condensation agent.

  本发明涉及一种生产能够抑制靶基因表达的发夹型单链 RNA 分子的方法，包括以下步骤： 在由缓冲溶液和亲水性有机溶剂组成的混合溶剂中，在脱水缩合剂存在的情况下，由下式 (I) 表示的第一单链寡核苷酸分子与由下式 (II) 表示的第二单链寡核苷酸分子反应： 5'-Xc-Lx1 ...... (I) 和 Lx2-X-Y-Ly-Yc-3' ...... (II) ，其中脱水缩合剂选自由三嗪类脱水缩合剂、脲类脱水缩合剂、脲类脱水缩合剂和脲类脱水缩合剂组成的组。...(I)和 Lx2-X-Y-Ly-Yc-3' ...(II)，其中脱水缩合剂选自由三嗪基脱水缩合剂、包含 N-羟基含氮芳香环结构的脲基脱水缩合剂、碳二亚胺基脱水缩合剂、2-卤代吡啶鎓基脱水缩合剂和甲脒基脱水缩合剂组成的组。
• JAKOBSEN, MOGENS HAVSTEEN;BUCHARDT, OLE;HOLM, ARNE;MELDAL, MORTEN, SYNTHESIS,(1990) N1, C. 1008-1010
  作者：JAKOBSEN, MOGENS HAVSTEEN、BUCHARDT, OLE、HOLM, ARNE、MELDAL, MORTEN

  DOI：——

  日期：——
• METHOD OF PRODUCING HAIRPIN SINGLE-STRANDED RNA MOLECULES
  申请人：Toray Industries, Inc.

  公开号：US20210317495A1

  公开（公告）日：2021-10-14

  A method produces a hairpin single-stranded RNA molecule capable of inhibiting expression of a target gene, including the step of reacting a first single-stranded oligo-RNA molecule represented by formula (I) with a second single-stranded oligo-RNA molecule represented by formula (II) in a mixed solvent including a buffer solution and a hydrophilic organic solvent in the presence of a dehydration condensation agent: 5′-Xc-Lx 1 (I) and Lx 2 -X—Y-Ly-Yc-3′ (II), wherein the dehydration condensation agent is selected from the group consisting of a triazine-based dehydration condensation agent, a uronium-based dehydration condensation agent including an N-hydroxy nitrogen-containing aromatic ring structure, a carbodiimide-based dehydration condensation agent, a 2-halopyridinium-based dehydration condensation agent, and a formamidinium-based dehydration condensation agent.
• US6403521B1
  申请人：——

  公开号：US6403521B1

  公开（公告）日：2002-06-11