<131>ICl | 19176-59-1

• 分子结构分类: 无机化合物
• 英文名称: <131>ICl
• CAS: 19176-59-1
• 化学式: ClI
• 分子量: 166.453
• InChiKey: QZRGKCOWNLSUDK-XKBLRHCCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.58
• 重原子数：
  2.0
• 可旋转键数：
  0.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为产物：
  描述：

  氯 、 cesium iodide 以 四氯化碳 为溶剂， 生成 iodine-131 、 、 <131>ICl
  参考文献：
  名称：

  Mikheev, N. B.; Kamenskaya, A. N.; Kulyukhin, S. A., Radiochemistry, 2000, vol. 42, p. 396 - 400

  摘要：

  DOI：
• 作为试剂：
  描述：

  N,N-二甲基-2-(2,5-二甲氧基苯基)异丙胺 在 高氯酸 、 <131>ICl 作用下， 以 溶剂黄146 为溶剂， 生成 N,N-dimethyl-2-(4-<131I>iodo-2,5-dimethoxyphenyl)isopropylamine
  参考文献：
  名称：

  Radiohalogen-labeled imaging agents. 3. Compounds for measurement of brain blood flow by emission tomography

  摘要：

  The radioiodine-labeled amines currently available as brain-imaging agents, based on our previous work and that of others, are prepared either by exchange labeling or by direct iodination of a protected intermediate. The intrinsic slowness of these processes limits their potential for use with the positron-emitting 122I, as it has a half-life of only 3.6 min. This isotope has advantages of a low dose to the patient and availability from a generator containing the parent 20-h 122Xe. To develop a radiopharmaceutical in which 122I could be utilized, we prepared a number of secondary and tertiary amines (maintaining the 2,5-dimethoxy substitution pattern which allows direct iodination at the 4-position) with 131I. The organ distributions of these compounds were studied, and the best properties were found in the N,N-dimethyl homologue (2,5-dimethoxy-N,N-dimethyl-4-iodoamphetamine). This compound was successfully synthesized in a matter of seconds, with a chemical yield and radioactive purity both in excess of 90% and an incorporation efficiency of radioiodine of about 40%.

  DOI：

  10.1021/jm00374a023