3-Methyl-1,2,3,4-tetrahydro-chinazolin | 1904-67-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-Methyl-1,2,3,4-tetrahydro-chinazolin
• 英文别名: 3-methyl-1,2,3,4-tetrahydro-quinazoline；3-Methyl-dihydroquinazoline；3-methyl-2,4-dihydro-1H-quinazoline
• CAS: 1904-67-2
• 化学式: C₉H₁₂N₂
• 分子量: 148.208
• InChiKey: WNUQJYZEFOTKBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-Methyl-1,2,3,4-tetrahydro-chinazolin 在 lead(IV) acetate 、 溶剂黄146 作用下， 生成 3-甲基-3,4-二氢喹唑啉
  参考文献：
  名称：

  Osborn; Schofield, Journal of the Chemical Society, 1956, p. 3977

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基-N-甲基苯甲酰胺 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 50.0h， 生成 3-Methyl-1,2,3,4-tetrahydro-chinazolin
  参考文献：
  名称：

  Synthe`se ete´tudein vitro de l'activite´antiagre´gante plaquettaire de de´rive´s de la te´trahydro-1,2,3,4 quinazoline

  摘要：

  DOI：

  10.1016/0223-5234(89)90058-5

文献信息

• DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS
  申请人：Chiesi Farmaceutici S.p.A.

  公开号：US20130102576A1

  公开（公告）日：2013-04-25

  Compounds, pyridine N-oxides, and pharmaceutically acceptable salts of formula (I) are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and for preventing and/or treating diseases of the respiratory tract characterized by airway obstruction, such as asthma or COPD.

  化合物，吡啶N-氧化物和具有以下结构的药学上可接受的盐（I）的盐对于抑制磷酸二酯酶4（PDE4）酶并预防和/或治疗呼吸道疾病，其特征是气道阻塞，如哮喘或COPD，是有用的。
• Compounds Useful as Antagonists of CCR2
  申请人：Sprott Kevin

  公开号：US20100016289A1

  公开（公告）日：2010-01-21

  The present invention provides compounds of general formula I: (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R 1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR 2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.

  本发明提供一般式I的化合物：（I）或其药学上可接受的盐，其中X、n、Y和R1在此通常和子集中定义。本发明的化合物是CCR2的抑制剂，因此可用于治疗各种炎症、过敏和自身免疫性疾病、紊乱或状况。
• COMPOUNDS USEFUL AS ANTAGONISTS OF CCR2
  申请人：Ghosh Shomir

  公开号：US20120214807A1

  公开（公告）日：2012-08-23

  The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R 1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.

  本发明提供了一般式I的化合物：或其药学上可接受的盐，其中X，n，Y和R1在此总体上和子集中被定义。本发明的化合物是CCR2的抑制剂，因此可用于治疗各种炎症、过敏和自身免疫性疾病、障碍或病况。
• SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS
  申请人：Borzilleri Robert M.

  公开号：US20140135318A1

  公开（公告）日：2014-05-15

  Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.

  本发明涉及式（I）的化合物或其药学上可接受的盐，其中：W、Q和G的定义如下。还公开了使用这些化合物作为Bcl-2家族抗凋亡蛋白的抑制剂用于治疗癌症的方法；以及包含这些化合物的药物组合物。
• Capsazepine analogs for the treatment of cancer and other proliferative diseases
  申请人：THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

  公开号：US10457676B2

  公开（公告）日：2019-10-29

  The present disclosure relates generally to derivatives of capsazepine and methods of use thereof In some aspects, the present disclosure relates to using capsazepine derivatives to treat cancer or other hyperproliferative diseases. In some aspects of the present disclosure, the disclosure provides capsazepine derivatives which may be useful in the treatment of cancer. Such cancers that the compounds may be used to treating include but are not limited to breast, cervical, oral, head, neck, or prostate cancer. In some aspects, the compounds may be useful in treating a tumor by direct injection of the compound into the tumor, particularly an oral tumor. In other aspects, the compounds are administered systemically. The compounds of the present disclosure may also be used to treat the pain associated with a tumor for which it is being administered.

  本公开总体上涉及卡扎西平的衍生物及其使用方法 在某些方面，本公开涉及使用卡扎西平衍生物治疗癌症或其他增殖过度疾病。在本公开的某些方面，本公开提供了可用于治疗癌症的卡氮平类衍生物。这些化合物可用于治疗的癌症包括但不限于乳腺癌、宫颈癌、口腔癌、头颈癌或前列腺癌。在某些方面，通过将化合物直接注射到肿瘤，特别是口腔肿瘤中，化合物可用于治疗肿瘤。在其他方面，化合物可全身给药。本公开的化合物还可用于治疗与所给药的肿瘤相关的疼痛。