dioleoylphosphatidyl ethanolamine | 7736-17-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: dioleoylphosphatidyl ethanolamine
• 英文别名: 2-aminoethyl 2,3-bis[(Z)-octadec-9-enoxy]propyl hydrogen phosphate
• CAS: 7736-17-6
• 化学式: C₄₁H₈₂NO₆P
• 分子量: 716.079
• InChiKey: SHCCKWGIFIPGNJ-CLFAGFIQSA-N

物化性质

• 沸点：
  735.8±70.0 °C(Predicted)
• 密度：
  0.962±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  11.3
• 重原子数：
  49
• 可旋转键数：
  41
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• RECOMBINANT EXPRESSION VECTOR AND LIPID MEMBRANE STRUCTURE HAVING SAID VECTOR ENCAPSULATED THEREIN
  申请人：National University Corporation Hokkaido University

  公开号：EP3382020A1

  公开（公告）日：2018-10-03

  [Problem] To provide a novel expression vector capable of effectively expressing a target protein in mitochondria and suppressing undesirable expression of the target protein in cell organelles other than mitochondria. [Solution] The present invention provides a recombinant expression vector for expressing a target protein in mitochondria of animal cells, and a lipid membrane structure having the vector encapsulated therein, wherein the recombinant expression vector has a promoter sequence exhibiting a transcription activity in the nuclei of animal cells, and has, under the control of the promoter sequence, a coding region which codes a target protein and includes one or more TGAs as codons corresponding to tryptophan. The recombinant expression vector according to the present invention can more efficiently and selectively express a target protein in mitochondria, and can be used as a more safe and effective drug for treating mitochondrial diseases.

  问题 提供一种新型表达载体，该载体能够在线粒体中有效表达目标蛋白，并抑制目标蛋白在线粒体以外的细胞器中的不良表达。 [解决方案］ 本发明提供了一种用于在动物细胞线粒体中表达目的蛋白的重组表达载体，以及一种将该载体封装在其中的脂膜结构，其中重组表达载体具有在动物细胞核中表现出转录活性的启动子序列，并且在启动子序列的控制下具有编码目的蛋白的编码区，该编码区包括一个或多个作为与色氨酸相对应的密码子的TGA。根据本发明的重组表达载体可以更有效、更有选择性地在线粒体中表达目标蛋白，可用作治疗线粒体疾病的更安全有效的药物。
• NOVEL CRISPR ENZYMES AND SYSTEMS
  申请人：The Broad Institute, Inc.

  公开号：EP3500670A1

  公开（公告）日：2019-06-26
• SYSTEMS, METHODS, AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITING
  申请人：The Broad Institute, Inc.

  公开号：EP3625343A1

  公开（公告）日：2020-03-25
• CRISPR/CAS-ADENINE DEAMINASE BASED COMPOSITIONS, SYSTEMS, AND METHODS FOR TARGETED NUCLEIC ACID EDITING
  申请人：The Broad Institute, Inc.

  公开号：EP3645054A1

  公开（公告）日：2020-05-06
• CELL ATLAS OF HEALTHY AND DISEASED BARRIER TISSUES
  申请人：Massachusetts Institute of Technology

  公开号：EP3655961A1

  公开（公告）日：2020-05-27