2'-deoxy-2'-fluorocytidine | 1056152-04-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 2'-deoxy-2'-fluorocytidine
• 英文别名: 2'-Fluoro-2'-deoxycyti-dine；4-amino-1-[(2R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
• CAS: 1056152-04-5
• 化学式: C₉H₁₂FN₃O₄
• 分子量: 245.21
• InChiKey: NVZFZMCNALTPBY-RNMRRNDGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2'-deoxy-2'-fluorocytidine 生成 N4-benzoyl-2'-deoxy-2'-fluorocytidine
  参考文献：
  名称：

  Antisense modulation of hepatoma-derived growth factor expression

  摘要：

  提供了用于调节肝癌源性生长因子表达的反义化合物、组合物和方法。这些组合物包括针对编码肝癌源性生长因子的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节肝癌源性生长因子表达以及治疗与肝癌源性生长因子表达相关疾病的方法。

  公开号：

  US20040023379A1
• 作为产物：
  描述：

  2'-deoxy-2'-fluorouridine 生成 2'-deoxy-2'-fluorocytidine
  参考文献：
  名称：

  Antisense modulation of hepatoma-derived growth factor expression

  摘要：

  提供了用于调节肝癌源性生长因子表达的反义化合物、组合物和方法。这些组合物包括针对编码肝癌源性生长因子的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节肝癌源性生长因子表达以及治疗与肝癌源性生长因子表达相关疾病的方法。

  公开号：

  US20040023379A1

文献信息

• [EN] COMPOSITIONS AND METHODS FOR SYNTHESIS OF PHOSPHORYLATED MOLECULES<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE SYNTHÈSE DE MOLÉCULES PHOSPHORYLÉES
  申请人：UNIV CALIFORNIA

  公开号：WO2019195494A1

  公开（公告）日：2019-10-10

  The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

  这项发明提供了合成磷酸化有机化合物的组合物和方法，包括核苷三磷酸。
• Dosing regimen for gemcitabine HCV therapy
  申请人：——

  公开号：US20030225029A1

  公开（公告）日：2003-12-04

  A dosage regiment for the treatment of a Flaviviridae infection, including a hepatitis C viral infection, that includes administering gemcitabine (or its salt, prodrug or derivative, as described herein) in a dosage range of approximately 50 mg/m 2 to about 1300 mg/m 2 per day for between one and seven days (e.g. 1, 2, 3, 4, 5, 6, or 7 days) followed by cessation of therapy. Viral load is optionally monitored over time, and after cessation, viral rebound is monitored. Therapy is not resumed unless a significant viral load is again observed, and then therapy for 1-7 days and more preferred, 1, 2 or 3 days, is repeated. This therapy can be continued indefinitely to monitor and maintain the health of the patient.

  一种用于治疗黄病毒科感染的剂量方案，包括丙型肝炎病毒感染，在一到七天内每天给予吉西他滨（或其盐、前药或衍生物，如本文所述）的剂量范围约为50毫克/平方米至约1300毫克/平方米，随后停止治疗。可选择随时间监测病毒载量，并在停止治疗后监测病毒反弹。除非再次观察到显著的病毒载量，否则不会恢复治疗，然后重复1-7天的治疗，更倾向于1、2或3天。这种疗法可以无限期地继续以监测和维护患者的健康。
• [EN] NUCLEIC ACID CHEMICAL MODIFICATIONS<br/>[FR] MODIFICATIONS CHIMIQUES D'ACIDE NUCLÉIQUE
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2010101951A1

  公开（公告）日：2010-09-10

  he present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.

  本发明提供了式（1）的核苷和包含至少一种式（2）核苷的寡核苷酸；发明的另一个方面涉及一种抑制细胞中基因表达的方法，该方法包括（a）将本发明的寡核苷酸与细胞接触；和（b）维持步骤（a）中的细胞足够长的时间以获得目标基因mRNA的降解。
• Nucleotide mimics and their prodrugs
  申请人：——

  公开号：US20040059104A1

  公开（公告）日：2004-03-25

  The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or base-modifications. The nucleotide mimics of the present invention, in a form of a pharmaceutically acceptable salt, a pharmaceutically acceptable prodrug, or a pharmaceutical formulation, are useful as antiviral, antimicrobial, and anticancer agents. The present invention provides a method for the treatment of viral infections, microbial infections, and proliferative disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of the present invention optionally in combination with other pharmaceutically active agents.

  本发明涉及核苷二磷酸模拟物和核苷三磷酸模拟物，其中包含二磷酸或三磷酸基团模拟物，以及可选的糖修饰和/或碱基修饰。本发明的核苷酸模拟物，以药学上可接受的盐、药学上可接受的前药或药物配方的形式，可用作抗病毒、抗微生物和抗癌剂。本发明提供了一种治疗病毒感染、微生物感染和增生性疾病的方法。本发明还涉及包含本发明化合物的药物组合物，可选地与其他药理活性剂结合。
• Oligonucleotides having modified nucleoside units
  申请人：——

  公开号：US20040014957A1

  公开（公告）日：2004-01-22

  Disclosed are oligonucleotides and oligonucleosides that include one or more modified nucleoside units. The oligonucleotides and oligonucleosides are particularly useful as antisense agents, ribozymes, aptamer, siRNA agents, probes and primers or, when hybridized to an RNA, as a substrate for RNA cleaving enzymes including RNase H and dsRNase.

  披露的是包括一个或多个修饰核苷单元的寡核苷酸和寡核苷糖。这些寡核苷酸和寡核苷糖特别适用于作为反义剂、核酶、适配体、siRNA试剂、探针和引物，或者当它们与RNA杂交时，作为包括RNase H和dsRNase的RNA切割酶的底物。