5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-(2-hydroxy-ethyl)-4,5-di-hydro-1 H-pyrazole-3-carboxylic acid piperidin-1-ylamide | 919508-52-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• 英文名称: 5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-(2-hydroxy-ethyl)-4,5-di-hydro-1 H-pyrazole-3-carboxylic acid piperidin-1-ylamide
• 英文别名: 3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-4-(2-hydroxyethyl)-N-piperidin-1-yl-3,4-dihydropyrazole-5-carboxamide
• CAS: 919508-52-4
• 化学式: C₂₃H₂₅Cl₃N₄O₂
• 分子量: 495.836
• InChiKey: KVQRIEMRNRZCHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Active substance combination for the treatment of diabetes
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP1946778A1

  公开（公告）日：2008-07-23

  The present invention relates to an active substance combination comprising at least one substituted pyrazoline compound and at least one drug, used to treat diabetes, a medicament comprising said active substance combination, a pharmaceutical formulation comprising said active substance combination and the use of said active substance combination for the manufacture of a medicament.

  本发明涉及一种活性物质组合，包括至少一种取代吡唑啉化合物和至少一种药物，用于治疗糖尿病，包括该活性物质组合的药物、包括该活性物质组合的制药配方以及利用该活性物质组合制造药物的用途。
• Substituted pyrazoline for preventing weight gain
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP1946777A1

  公开（公告）日：2008-07-23

  The present invention relates to an active substance combination comprising at least one substituted pyrazoline compound and at least one drug, known to produce weight-gain as a side effect, a medicament comprising said active substance combination, a pharmaceutical formulation comprising said active substance combination and the use of said active substance combination for the manufacture of a medicament.

  本发明涉及一种活性物质组合，包括至少一种取代吡唑啉化合物和至少一种药物，该药物以体重增加作为副作用而知名，包括所述活性物质组合的药物、包括所述活性物质组合的药物制剂、以及利用所述活性物质组合制造药物。
• 4,5-Dihydro-1H-pyrazole derivatives, their preparation and use as medicaments
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1743890A1

  公开（公告）日：2007-01-17

  The present invention relates to 4-substituted pyrazoline compounds of formula I methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

  本发明涉及公式I的4-取代吡唑烷化合物及其制备方法，包括这些化合物的药物以及它们用于制备治疗人类和动物药物的药物的用途。
• 4-Substituted Pyrazoline Compounds, their Preparation and Use as Medicaments
  申请人：TORRENS Antoni

  公开号：US20070073056A1

  公开（公告）日：2007-03-29

  The present invention relates to 4-substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

  本发明涉及4-取代吡唑啉化合物，其制备方法，包含这些化合物的药物以及它们用于制备用于治疗人类和动物的药物的用途。