1,2-dihydroclobetasone 17-butyrate | 639817-48-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 1,2-dihydroclobetasone 17-butyrate
• 英文别名: 1,2-Dihydroclobetasone butyrate；[(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] butanoate
• CAS: 639817-48-4
• 化学式: C₂₆H₃₄ClFO₅
• 分子量: 481.004
• InChiKey: APQSIYKUWQYHMT-AVVSTMBFSA-N

反应信息

• 作为产物：
  描述：

  丁酸倍氯他松 在 5%-palladium/activated carbon 作用下， 以 乙醇 为溶剂， 反应 70.0h， 以42%的产率得到1,2-dihydroclobetasone 17-butyrate
  参考文献：
  名称：

  Synthesis and Characterisation of Impurities of Manufacture in Support of Certificate of the European Pharmacopoeia Applications Part 1 (Clobetasone Butyrate)

  摘要：

  Established pharmaceutical products often have complex supply chains and regulatory histories. In Europe the European Directorate for the Quality of Medicine (EDQM) (information from European Pharmacopoeia website, http://www.pheur.org/) have promoted the use of certificates of suitability of the European Pharmacopoeia to ensure the quality of medicines by a commonly recognised set of standards, allowing the free movement of medicinal products in member states. This contribution describes the analytical and synthetic chemistry required to synthesise the impurities of manufacture of clobetasone butyrate.

  DOI：

  10.1021/op0341216