hydrochloric acid, methylene chloride | 160208-71-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: hydrochloric acid, methylene chloride
• 英文别名: Dichloromethane;hydron;chloride
• CAS: 160208-71-9
• 化学式: CH₂Cl₂*ClH
• 分子量: 121.394
• InChiKey: XLQDQRMFMXYSQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.84
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  1
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (S)-2-tert-butoxycarbonylamino-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl]propionic acid methyl ester 、 hydrochloric acid, methylene chloride 在 二氯甲烷 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以to obtain the title compound (0.84 g, 82%) as a white solid的产率得到methyl (2S)-2-amino-3-[4-(1,3,4-trimethyl-2,6-dioxo-pyrimidin-5-yl)phenyl]propanoate
  参考文献：
  名称：

  SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

  摘要：

  提供的是一种磺酰胺衍生物，其化学结构式如下（1），具有高选择性的α4整合素抑制作用，对α4β1的作用很小，对α4β7的作用很大，或其药学上可接受的盐（在通式（1）中，A、B、D、E、R41和a到h如说明书所述）。

  公开号：

  US20160244451A1
• 作为试剂：
  描述：

  methyl tri-O-benzoyl-α-D-arabinofuranoside 在 2,6-二甲基吡啶 、 甲醇 、 hydrochloric acid, methylene chloride 、 乙酰溴 、 四丁基碘化铵 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  Facile Synthesis of β- and α-Arabinofuranosides and Application to Cell Wall Motifs of M. tuberculosis

  摘要：

  Propargyl 1,2-orthoesters of arabinose are exploited for the synthesis of 1,2-trans furanosides; easily accessible 1,2-trans ribofuranosides are converted to challenging 1,2-cis-arabinofuranosides by oxidoreduction. Utility of these protocols was demonstrated by the successful synthesis of major structural motifs present in the cell surface of Mycobacterium tuberculosis. Key furanosylations were carried out under gold-catalyzed glycosidation conditions.

  DOI：

  10.1021/ol400931p

文献信息

• Pyrimidine derivatives, method of manufacturing the same, and androgen
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US05420128A1

  公开（公告）日：1995-05-30

  The invention discloses a pyrimidien derivative expressed in Formula [I]: ##STR1## where R.sup.1 denotes a hydrogen atom or hydroxyl group, R.sup.2 denotes a hydrogen atom, lower alkoxycarbonyl group, lower alkoxy group, halogen atom, lower alkyl group, cycloalkyl group with 3 to 8 carbon atoms, lower alkoxycarbonyl lower alkyl group, carboxyl group, carboxy lower alkyl group, group: --CONHR.sup.6 (R.sup.6 represents a hydrogen atom, a phenyl group, which may possess halogen atom, or lower alkyl group), cyano group, phenyl group which may possess a group selected from the group consisting of hydroxyl group, halogen atom, lower alkyl group, lower alkoxy group and phenylthio group as a substituent, phenyl lower alkyl group which may possess a group selected from the group consisting of hydroxyl group and lower alkoxy group as a substituent on a phenyl ring, lower alkanoyloxy lower alkyl group, benzoyl group, lower alkanoyl group which may possess a halogen atom, or hydroxy lower alkyl group which may possess a group selected from the group consisting of phenyl group and halogen atom as a substituent, R.sup.3 denotes a hydrogen atom, hydroxyl group, lower alkyl group, cycloalkyl group with 3 to 8 carbon atoms, halogen lower alkyl group, or phenyl group, R.sup.4 denotes a hydrogen atom, lower alkyl group, or lower alkoxy group, and R.sup.5 denotes a hydrogen atom, lower alkyl group, lower alkoxy lower alkyl group, or halogen lower alkyl group; provided that R.sup.2 and R.sup.3 may be bonded to each other to form a lower alkylene group with 3 to 5 carbon atoms, or its pharmaceutically available salt. This derivative is excellent in therapeutic effects of benign prostatic hypertrophy, prostatic carcinoma, female hairiness, male baldness or pimple as an androgen inhibitor.

  该发明揭示了一个在式[I]中表示的嘧啶衍生物：其中R.sup.1表示氢原子或羟基，R.sup.2表示氢原子、低烷氧羰基基团、低烷氧基、卤原子、低烷基、具有3至8个碳原子的环烷基、低烷氧羰基低烷基、羧基、羧基低烷基、基团：--CONHR.sup.6（R.sup.6代表氢原子、苯基，可能带有卤原子，或低烷基），氰基、苯基，可能带有羟基、卤原子、低烷基、低烷氧基和苯硫基等取代基的基团，苯基低烷基基团，可能在苯环上带有羟基和低烷氧基等取代基的基团，低烷酰氧基低烷基基团，苯甲酰基、低烷酰基，可能带有卤原子，或羟基低烷基基团，可能带有苯基和卤原子等取代基的基团，R.sup.3表示氢原子、羟基、低烷基、具有3至8个碳原子的环烷基、卤基低烷基，或苯基，R.sup.4表示氢原子、低烷基，或低烷氧基，R.sup.5表示氢原子、低烷基，低烷氧低烷基，或卤基低烷基；条件是R.sup.2和R.sup.3可以连接在一起形成具有3至5个碳原子的低烷基，或其药用可用盐。该衍生物在治疗良性前列腺肥大、前列腺癌、女性多毛症、男性秃发或痤疮等方面作为雄激素抑制剂具有出色的疗效。
• Substituted heterocyclylisoquinolinium salts and compositions and
  申请人：Sterling Winthrop Inc.

  公开号：US05604224A1

  公开（公告）日：1997-02-18

  Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.

  替代杂环异喹啉盐，含有它们的制药组合物以及利用它们治疗或预防神经退行性疾病或神经毒性损伤的方法。
• Substituted 6,11-ethano-6,11-dihydrobenzo[B]quinolizinium salts and
  申请人：Sanofi Winthrop, Inc.

  公开号：US05631264A1

  公开（公告）日：1997-05-20

  Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.

  该专利描述了6,11-乙烷基-6,11-二氢苯并[b]喹啉盐的替代物，含有它们的制药组合物以及利用它们治疗或预防神经退行性疾病或神经毒性损伤的方法。
• Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts and
  申请人：Sterling Winthrop Inc.

  公开号：US05554620A1

  公开（公告）日：1996-09-10

  Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment of neurodegenerative disorders or neurotoxic injuries utilizing them, wherein the substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts have the formula: ##STR1## wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X and p are as defined in the specification.

  替代6,11-乙烷基-6,11-二氢苯并[b]喹啉盐，含有它们的制药组合物，以及利用它们治疗神经退行性疾病或神经毒性损伤的方法，其中替代的6,11-乙烷基-6,11-二氢苯并[b]喹啉盐的化学式为：##STR1## 其中：R.sup.1、R.sup.2、R.sup.3、R.sup.4、R.sup.5、R.sup.6、R.sup.7、X和p如规范中所定义。
• Substituted heterocyclylisoquinolinium salts and compositions and method
  申请人：Sterling Winthrop Inc.

  公开号：US05569655A1

  公开（公告）日：1996-10-29

  Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.

  替代杂环异喹啉盐，含有它们的药物组合物以及利用它们治疗或预防神经退行性疾病或神经毒性损伤的方法。