2-{5,6-dimethyl-4-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl}-6-fluoroquinazoline | 1149352-61-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并-1,2,3-三嗪类化合物
• 英文名称: 2-{5,6-dimethyl-4-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl}-6-fluoroquinazoline
• 英文别名: [4-(6-Fluoroquinazolin-2-yl)-6,7-dimethyl-1,4-diazepan-1-yl]-[2-(triazol-2-yl)phenyl]methanone
• CAS: 1149352-61-3
• 化学式: C₂₄H₂₄FN₇O
• 分子量: 445.499
• InChiKey: WQLXFCZJXRBFHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  80
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] SUBSTITUTED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DES RÉCEPTEURS DE L'OREXINE, DE TYPE DIAZÉPAN SUBSTITUÉ
  申请人：MERCK & CO INC

  公开号：WO2009058238A1

  公开（公告）日：2009-05-07

  The present invention is directed to diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which orexin receptors are involved.

  本发明涉及一种二氮平化合物，其为促进睡眠激素受体的拮抗剂，并且在治疗涉及促进睡眠激素受体的神经和精神障碍和疾病方面具有用途。本发明还涉及包括这些化合物的制药组合物以及在治疗涉及促进睡眠激素受体的这些疾病方面使用这些化合物和组合物。
• SUBSTITUTED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS
  申请人：Bergman Jeffrey M.

  公开号：US20100256121A1

  公开（公告）日：2010-10-07

  The present invention is directed to diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which orexin receptors are involved.

  本发明涉及一种二氮平化合物，其是促进睡眠的药物，可以作为促进睡眠的治疗药物。该化合物是促进睡眠的药物，可以用于治疗神经系统和精神障碍和疾病，这些疾病中涉及到促进睡眠的药物。本发明还涉及包含这些化合物的制药组合物以及在治疗涉及到促进睡眠的疾病时使用这些化合物和组合物的方法。
• US8362009B2
  申请人：——

  公开号：US8362009B2

  公开（公告）日：2013-01-29