1-[([2,2']bipyridinyl-6-yl)methyl]-3-methyl-7-(but-2-ynyl)-8-[(R)-3-(tert-butoxycarbonylamino)-piperidin-1-yl]-xanthine | 864779-37-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 1-[([2,2']bipyridinyl-6-yl)methyl]-3-methyl-7-(but-2-ynyl)-8-[(R)-3-(tert-butoxycarbonylamino)-piperidin-1-yl]-xanthine
• 英文别名: 1-[([2,2']bipyridinyl-6-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butyloxycarbonylamino)-piperidin-1-yl]-xanthine；tert-butyl N-[(3R)-1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-[(6-pyridin-2-ylpyridin-2-yl)methyl]purin-8-yl]piperidin-3-yl]carbamate
• CAS: 864779-37-3
• 化学式: C₃₁H₃₆N₈O₄
• 分子量: 584.678
• InChiKey: LVKFTMYBOZTJFC-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  126
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
  申请人：HIMMELSBACH Frank

  公开号：US20090137801A1

  公开（公告）日：2009-05-28

  Disclosed are substituted xanthines of the formula wherein R is defined as in claim 1 , the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

  本发明涉及一种公式如下的取代黄嘌呤：其中R如权利要求1所定义，其互变异构体、立体异构体、混合物及其盐，具有有价值的药理学特性，特别是对酶二肽基肽酶-IV（DPP-IV）的抑制作用。
• Hydroscopic polymer gels for easier cleaning
  申请人：Rodrigues A. Klin

  公开号：US20050245428A1

  公开（公告）日：2005-11-03

  Hydroscopic polymer gels can be formed by applying a polymer to a surface and allowing water to be sequestered from the atmosphere into the polymer. The polymer gels are formed using methods and compositions employing water soluble or water dispersible copolymers having: (i) a first monomer that is acidic and is capable of forming an anionic charge in the composition; (ii) a second monomer that is amphipathic; (iii) optionally, a third monomer that is hydrophobic; and (iv) optionally, a fourth monomer that that has a permanent cationic charge or that is capable of forming a cationic charge on protonation. The polymer gels are particularly substantive and effective at modifying surfaces such as glass and hydrophobic polymeric substrates to provide soap scum and soil resistance, and easier next time cleaning benefits.

  将聚合物涂抹在表面上，让水从大气中渗入聚合物中，可形成吸水聚合物凝胶。形成聚合物凝胶的方法和组合物采用水溶性或水分散性共聚物，这些共聚物具有：(i) 酸性且能在组合物中形成阴离子电荷的第一单体；(ii) 两性离子的第二单体；(iii) 可选的疏水性第三单体；(iv) 可选的具有永久阳离子电荷或能在质子化时形成阳离子电荷的第四单体。聚合物凝胶对玻璃和疏水性聚合物基材等表面的改性特别有效，可提供耐肥皂浮渣和污垢性，并使下次清洁更容易。
• US7501426B2
  申请人：——

  公开号：US7501426B2

  公开（公告）日：2009-03-10
• US8697868B2
  申请人：——

  公开号：US8697868B2

  公开（公告）日：2014-04-15