5-hydroxy-2-(2-morpholin-4-yl-ethyl)-benzo[de]isoquinoline-1,3-dione | 69408-97-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 5-hydroxy-2-(2-morpholin-4-yl-ethyl)-benzo[de]isoquinoline-1,3-dione
• 英文别名: 5-Hydroxy-2-(2-morpholin-4-ylethyl)benzo[de]isoquinoline-1,3-dione
• CAS: 69408-97-5
• 化学式: C₁₈H₁₈N₂O₄
• 分子量: 326.352
• InChiKey: LLAOEHZCJKFBCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-(2-氨基乙基)吗啉 、 3-羟基-1,8-萘二甲酸酐 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 16.0h， 生成 5-hydroxy-2-(2-morpholin-4-yl-ethyl)-benzo[de]isoquinoline-1,3-dione
  参考文献：
  名称：

  An off-on fluorescent probe for real-time sensing the fluctuations of intracellular pH values in biological processes

  摘要：

  Minute fluctuation in the intracellular pH is usually related to common diseases. The construction of fluorescent probes with wide response range, high selectivity, excellent sensitivity and good reversibility for intracellular pH detection is of great significance. In this work, we developed a novel pH probe (ZJ) based on a 3-hydroxy naphthalimide derivative via the optimization of substitute groups. ZJ showed a satisfying fluorescence performance to pH changes. ZJ manifests a remarkable fluorescence enhancement at 468 nm (over 12-fold) from pH 2.5 to 10.0. Live cell imaging data uncovered that ZJ can be successfully used in monitoring intracellular pH changes led by chloroquine, inflammation and autophagy, and confirmed with flow cytometry analysis. All these features render ZJ a potential candidate to study pH-associated drug development and physiological and pathological processes.

  DOI：

  10.1016/j.dyepig.2019.107620

文献信息

• Fernandez Brana; Martinez Sanz; Castellano, European Journal of Medicinal Chemistry, 1981, vol. 16, # 3, p. 207 - 212
  作者：Fernandez Brana、Martinez Sanz、Castellano、et al.

  DOI：——

  日期：——
• BRANA M. F.; SANZ A. M.; CASTELLANO J. M.; ROLDAN C. M.; ROLDAN C., EUR. J. MED. CHEM.-CHIM. THER., 1981, 16, NO 3, 207-212,
  作者：BRANA M. F.、 SANZ A. M.、 CASTELLANO J. M.、 ROLDAN C. M.、 ROLDAN C.

  DOI：——

  日期：——