methyl 4-(N,N-dimethylamino)benzenecarbothioate | 182114-86-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: methyl 4-(N,N-dimethylamino)benzenecarbothioate
• 英文别名: O-methyl 4-(dimethylamino)benzenecarbothioate
• CAS: 182114-86-9
• 化学式: C₁₀H₁₃NOS
• 分子量: 195.285
• InChiKey: TYTMAAUWCVPBKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  44.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-二甲氨基苯甲酸甲酯 在 tetraphosphorus decasulfide 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 12.0h， 以86%的产率得到methyl 4-(N,N-dimethylamino)benzenecarbothioate
  参考文献：
  名称：

  P4S10/dimethicone tandem: efficient reagent for thionation of various aromatic amides and esters

  摘要：

  Organosulfur compounds are valuable because of their rich and varied chemistry especially in biological field. We report a new and efficient way for thionation of various aromatic amides and esters using P4S10/dimethicone tandem. The ease of handling and higher yield makes this protocol economical. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.05.100

文献信息

• P4S10/dimethicone tandem: efficient reagent for thionation of various aromatic amides and esters
  作者：Dongho Cho、Jiyoung Ahn、Kathlia A. De Castro、Hyunseok Ahn、Hakjune Rhee

  DOI：10.1016/j.tet.2010.05.100

  日期：2010.7

  Organosulfur compounds are valuable because of their rich and varied chemistry especially in biological field. We report a new and efficient way for thionation of various aromatic amides and esters using P4S10/dimethicone tandem. The ease of handling and higher yield makes this protocol economical. (C) 2010 Elsevier Ltd. All rights reserved.