trans-[(NH3)2Pt(7,9-dimethylguaninium-N1)(1-methylthymine-N3)]ClO4 | 496916-02-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: trans-[(NH3)2Pt(7,9-dimethylguaninium-N1)(1-methylthymine-N3)]ClO4
• CAS: 496916-02-0
• 化学式: C₁₃H₂₂N₉O₃Pt*ClO₄
• 分子量: 646.907
• InChiKey: VVPCLAVBAFPVCN-UHFFFAOYSA-L

反应信息

• 作为产物：
  描述：

  trans-[(NH3)2Pt(1-methylthymine-N3)Cl] 、 sodium perchlorate 、 7,9-dimethylguanine 在 silver nitrate 作用下， 以 水 为溶剂， 以51.9%的产率得到trans-[(NH3)2Pt(7,9-dimethylguaninium-N1)(1-methylthymine-N3)]ClO4
  参考文献：
  名称：

  Hydrogen bonding patterns of 7,9-dimethylguanine and its transplatinum(II) complexes

  摘要：

  Methylation at the N7 position is one of the most frequently naturally occurring modifications of guanosine. This alteration drastically changes the hydrogen bonding and acid-base properties of the guanine nucleobase. Here we show on the example of the model nucleobase 7,9-dimethyl guanine that due to blockage of N7 of the purine ring, new hydrogen bonding patterns occur on the minor groove binding face of this nucleobase involving the ring nitrogen N3 and the exocyclic amino group N2H(2). The free 7,9-dimethylguaninium ion and several transplatinum(II) complexes of the this ligand are presented and discussed. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0020-1693(02)00962-3