4-(4-(2-(azetidin-1-yl)-1-(3,4-difluorophenyl)ethyl)piperazin-1-yl)-7,8-dihydropteridin-6(5H)-one | 1610452-70-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 4-(4-(2-(azetidin-1-yl)-1-(3,4-difluorophenyl)ethyl)piperazin-1-yl)-7,8-dihydropteridin-6(5H)-one
• 英文别名: 4-[4-[2-(azetidin-1-yl)-1-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-7,8-dihydro-5H-pteridin-6-one
• CAS: 1610452-70-4
• 化学式: C₂₁H₂₅F₂N₇O
• 分子量: 429.473
• InChiKey: VKTUQPSHTVFALU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  76.6
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] NOVEL HETEROCYCLIC DERIVATIVES AS MODULATORS OF KINASE ACTIVITY<br/>[FR] NOUVEAUX DÉRIVÉS HÉTÉROCYCLIQUES COMME MODULATEURS DE L'ACTIVITÉ KINASE
  申请人：MERCK PATENT GMBH

  公开号：WO2014078637A1

  公开（公告）日：2014-05-22

  The invention provides novel imidazol-piperidinyl derivatives of the formula (I) in which R1, R2, W, X1, X2, X3, X4 and n have the meanings indicated in formula (I), and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.

  该发明提供了公式（I）中的新型咪唑-哌啶衍生物，其中R1、R2、W、X1、X2、X3、X4和n具有公式（I）中所示的含义，并且它们的制造和用于治疗高增殖性疾病，如癌症。
• Novel Heterocyclic Derivatives as Modulators of Kinase Activity
  申请人：LAN Ruoxi

  公开号：US20150274750A1

  公开（公告）日：2015-10-01

  The invention provides novel imidazol-piperidinyl derivatives of the formula (I) in which R 1 , R 2 , W, X 1 , X 2 , X 3 , X 4 and n have the meanings indicated in formula I, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.

  本发明提供了公式（I）的新型咪唑-哌啶衍生物，其中R1，R2，W，X1，X2，X3，X4和n具有公式I中所示的含义，并且其制备和用于治疗增生性疾病，如癌症。
• Heterocyclic derivatives as modulators of kinase activity
  申请人：Merck Patent GmbH

  公开号：US10287300B2

  公开（公告）日：2019-05-14

  The invention provides novel imidazol-piperidinyl derivatives of the formula (I) in which R1, R2, W, X1, X2, X3, X4 and n have the meanings indicated in formula I, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.

  本发明提供了式 (I) 的新型咪唑-哌啶衍生物 其中 R1、R2、W、X1、X2、X3、X4 和 n 具有式 I 所示的含义，以及它们的制造和用于治疗过度增殖性疾病（如癌症）的用途。
• NOVEL HETEROCYCLIC DERIVATIVES AS MODULATORS OF KINASE ACTIVITY
  申请人：Merck Patent GmbH

  公开号：EP2920178A1

  公开（公告）日：2015-09-23
• NOVEL HETEROCYCLIC DERIVATIVES AS MODULATORS OF KINASE ACTIVITY (P70S6 AND AKT)
  申请人：Merck Patent GmbH

  公开号：EP2920178B1

  公开（公告）日：2016-12-21