5-cyano-furan-2-carboxylic acid methyl ester | 60838-00-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 5-cyano-furan-2-carboxylic acid methyl ester
• 英文别名: 5-carbomethoxy-furan-2-carbonitrile；Methyl 5-cyanofuran-2-carboxylate
• CAS: 60838-00-8
• 化学式: C₇H₅NO₃
• 分子量: 151.122
• InChiKey: WNBJXNGNGVOCKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-cyano-furan-2-carboxylic acid methyl ester 在 sodium azide 、 氯化铵 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 5-(1(2)H-tetrazol-5-yl)-furan-2-carboxylic acid methyl ester
  参考文献：
  名称：

  Povazanec,F. et al., Collection of Czechoslovak Chemical Communications, 1976, vol. 41, p. 1692 - 1697

  摘要：

  DOI：

文献信息

• Adenosine receptor ligands and their use in the treatment of disease
  申请人：——

  公开号：US20010027196A1

  公开（公告）日：2001-10-04

  The invention relates to cyclic heteroaromatic compounds, containing at least one nitrogen atom, and to their use in the manufacture of medicaments for the treatment of diseases, related to adenosine receptor modulators, such as Alzheimer's disease, Parkinson's disease, neuroprotection, schizophrenia, anxiety, pain, respiration deficits, depression, asthma, allergic responses, hypoxia, ischaemia, seizure, substance abuse, sedation and they may be active as muscle relaxants, antipsychotics, anti epileptics, anticonvulsants and cardiaprotective agents.

  这项发明涉及含有至少一个氮原子的环状杂芳化合物，以及它们在制造用于治疗与腺苷受体调节剂相关的疾病的药物中的应用，如阿尔茨海默病、帕金森病、神经保护、精神分裂症、焦虑、疼痛、呼吸功能障碍、抑郁症、哮喘、过敏反应、缺氧、缺血、癫痫、物质滥用、镇静，它们可能作为肌肉松弛剂、抗精神病药、抗癫痫药、抗惊厥药和心脏保护剂而具有活性。
• Inhibitors of farnesyl-protein transferase
  申请人：Merck & Co., Inc.

  公开号：US05939439A1

  公开（公告）日：1999-08-17

  The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

  本发明涉及抑制法尼基-蛋白转移酶（FTase）和致癌基因蛋白Ras法尼酰化的化合物。该发明还涉及含有本发明化合物的化疗组合物以及抑制法尼基-蛋白转移酶和致癌基因蛋白Ras法尼酰化的方法。
• Biocidal compositions containing a 2- (5'-nitro-2'-furyl)-thieno(2,3-d)
  申请人：Boehringer Ingelheim GmbH

  公开号：US03932642A1

  公开（公告）日：1976-01-13

  Biocidal pharmaceutical compositions containing as an active ingredient a compound of the formula ##SPC1## Wherein R is free amino; lower aliphatic acylamino optionally mono- or di-chloro-substituted on the acyl moiety; (straight or branched monoalkyl of 1 to 5 carbon atoms)-amino; di(alkyl of 1 to 4 carbon atoms)amino, where the alkyl moieties may be identical to or different from each other; mono- or di-hydroxy (straight or branched alkyl of 1 to 5 carbon atoms) amino, where the amino nitrogen may have an alkyl of 1 to 4 carbon atoms substituent attached thereto; di-[hydroxy (straight or branched alkyl of 1 to 3 carbon atoms)]amino; alkoxy of 1 to 2 carbon atoms (alkyl of 1 to 3 carbon atoms)amino; free amino (alkyl of 1 to 3 carbon atoms)amino; N-acetyl-(alkylene of 1 to 3 carbon atoms)-diamino; piperidino; or hydroxy-piperidino; and R.sub.1 and R.sub.2, which may be identical to or different from each other, are each hydrogen, methyl or ethyl Or a non-toxic, pharmacologically acceptable acid addition salt thereof, and methods of using the same as bactericides, fungicides and trichomonacides.

  含有化合物的生物杀菌制剂的活性成分的公式为##SPC1##其中R是自由氨基；在酰基部分上可以是较低的脂肪酰胺，可以是单氯或二氯取代的；(1至5个碳原子的直链或支链单烷基)-氨基；二(1至4个碳原子的烷基)氨基，其中烷基基团可以相同或不同；单或双羟基(1至5个碳原子的直链或支链烷基)氨基，其中氨基氮可以有1至4个碳原子的烷基取代基附着在其上；二-[羟基(1至3个碳原子的直链或支链烷基)]氨基；1至2个碳原子的烷氧基(1至3个碳原子的烷基)氨基；自由氨基(1至3个碳原子的烷基)氨基；N-乙酰基-(1至3个碳原子的亚烷基)-二氨基；哌啶基；或羟基哌啶基；R.sub.1和R.sub.2可以相同或不同，分别是氢、甲基或乙基，或其无毒、药理学上可接受的酸加成盐，以及将其用作杀菌剂、杀真菌剂和滴虫剂的方法。
• POVAZANEC F.; KOVAC J.; KRUTOSIKOVA A., COLLECT. CZECH. CHEM. COMMUNS <CCCC-AK>, 1976, 41, NO 6, 1692-1697
  作者：POVAZANEC F.、 KOVAC J.、 KRUTOSIKOVA A.

  DOI：——

  日期：——
• INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
  申请人：MERCK & CO., INC.

  公开号：EP0951285A1

  公开（公告）日：1999-10-27