APDA-10 | 35514-12-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: APDA-10
• 英文别名: N~1~-(3-Aminopropyl)decane-1,10-diamine；N'-(3-aminopropyl)decane-1,10-diamine
• CAS: 35514-12-6
• 化学式: C₁₃H₃₁N₃
• 分子量: 229.409
• InChiKey: ZLXQTPFBWNCSHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  64.1
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2921290000

反应信息

• 作为产物：
  描述：

  N-(2-Cyan-ethyl)-decandiyldiamin 在 镍 氨 、 氢气 作用下， 以 乙醇 为溶剂， 生成 APDA-10
  参考文献：
  名称：

  亚精和亚精的类似物。I.通过还原氰基化的α-α-二甲基乙二胺来合成聚乙烯亚胺。

  摘要：

  DOI：

  10.1021/jm00336a006

文献信息

• Novel treatment for pathologies associated with oxidative damage
  申请人：Wu Tianyun

  公开号：US20050143472A1

  公开（公告）日：2005-06-30

  This invention relates to compositions and methods for the treatment of pathologies associated with intracellular polyamine dysregulation. In particular, the present invention provides compositions and methods involving mammalian polyamine oxidase (PAO) to treat cancer, cell damage, tissue damage caused by ischemia/reperfusion, inflammation, traumatic brain injury, stroke and tissue developmental disorders. Methods for diagnosis and prognosis of cancer and other diseases are also provided by the present invention.

  本发明涉及用于治疗与细胞内多胺失调相关的病理的组合物和方法。特别地，本发明提供了利用哺乳动物多胺氧化酶（PAO）治疗癌症、细胞损伤、缺血/再灌注引起的组织损伤、炎症、创伤性脑损伤、中风和组织发育障碍的组合物和方法。本发明还提供了用于癌症和其他疾病的诊断和预后的方法。
• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, PREPARATION METHOD, AND USE
  申请人：Suzhou Ribo Life Science Co., Ltd.

  公开号：EP3974529A1

  公开（公告）日：2022-03-30

  An siRNA which inhibits kininogen (KNG) gene expression, a pharmaceutical composition containing the siRNA, and an siRNA conjugate. Each nucleotide in the siRNA is independently a modified or unmodified nucleotide. The siRNA contains a sense strand and an antisense strand. The sense strand contains nucleotide sequence I, nucleotide sequence I having the same length as the nucleotide sequence shown in SEQ ID NO: 1, with no more than three nucleotide differences. The antisense strand contains nucleotide sequence II, nucleotide sequence II having the same length as the nucleotide sequence shown in SEQ ID NO: 2, with no more than three nucleotide differences. The siRNA, the pharmaceutical composition thereof and the siRNA conjugate can effectively treat and/or prevent septicemia.

  一种抑制激肽原（KNG）基因表达的 siRNA、一种含有该 siRNA 的药物组合物以及一种 siRNA 结合物。siRNA 中的每个核苷酸都是独立的修饰或未修饰核苷酸。siRNA 包含有义链和反义链。有义链包含核苷酸序列 I，核苷酸序列 I 的长度与 SEQ ID NO: 1 所示的核苷酸序列相同，核苷酸差异不超过三个。反义链包含核苷酸序列 II，核苷酸序列 II 的长度与 SEQ ID NO: 2 所示的核苷酸序列相同，核苷酸差异不超过三个。siRNA 及其药物组合物和 siRNA 结合物可有效治疗和/或预防败血症。
• Biologically absorbable coatings for implantable devices and methods for fabricating the same
  申请人：Hossainy F.A. Syed

  公开号：US20070098758A1

  公开（公告）日：2007-05-03

  Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising a biologically degradable, biologically erodable, and/or biologically resorbable ABA or AB block copolymer. A biologically active agent can be conjugated to the block copolymer.
• BIOLOGICALLY ABSORBABLE COATINGS FOR IMPLANTABLE DEVICES AND METHODS FOR FABRICATING THE SAME
  申请人：Hossainy Syed F.A.

  公开号：US20080206307A1

  公开（公告）日：2008-08-28

  Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising a biologically degradable, biologically erodable, and/or biologically resorbable ABA or AB block copolymer. A biologically active agent can be conjugated to the block copolymer.