| 1415032-05-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• CAS: 1415032-05-1
• 化学式: C₂₀H₂₃N₉O₆S
• 分子量: 517.525
• InChiKey: CDSMYKZQNVJBNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.48
• 重原子数：
  36.0
• 可旋转键数：
  12.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  209.27
• 氢给体数：
  6.0
• 氢受体数：
  13.0

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 磺胺嘧啶 、 更昔洛韦 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  SYNTHESIS AND IN-VITRO STUDY OF SOME MEDICINALLY IMPORTANT MANNICH BASES DERIVED FROM 2-AMINO-9 [{(1, 3 DIHYDROXY PROPANE-2YL) OXY} METHYL] 6-9 DIHYDRO-3H-PURIN-6-ONE

  摘要：

  A series of biologically active Mannich bases with heteroaromatic ring system have been synthesized employing Mannich reaction of 2-amino-9 [{(1,3 dihydroxy propane-2yl) oxy} methyl] 6-9 dihydro-3H-purin-6-one (potent drug) with biologically active sulphonamides and secondary amines. They were analyzed by elemental analysis and characterized by spectral studies- UV, IR, H-1 NMR, Powder X-ray diffraction and Scanning Electron Microscopy. The Mannich bases were screened for their antibacterial activity against various gram + and gram - bacteria. The results had shown that the Mannich bases are quiet active against pathogens under study at varying concentrations. The toxicity of synthesized Mannich bases was ascertained by LD50 test.

  DOI：

  10.4067/s0717-97072012000300017