9-(2-bromo-3,4,5-trimethoxy-benzyl)-6-methoxy-9H-purine | 848695-45-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-(2-bromo-3,4,5-trimethoxy-benzyl)-6-methoxy-9H-purine
• 英文别名: 9-[(2-Bromo-3,4,5-trimethoxyphenyl)methyl]-6-methoxypurine
• CAS: 848695-45-4
• 化学式: C₁₆H₁₇BrN₄O₄
• 分子量: 409.239
• InChiKey: GFUCIHIIUIYLGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  80.5
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Deazapurine derivatives as HSP90-Inhibitors
  申请人：Conforma Therapeutics Corporation

  公开号：EP2145888A1

  公开（公告）日：2010-01-20

  Heterobicyclic compounds of formula I are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agent. Method of synthesis and use of such compounds are also described.

  描述并证明了式 I 的杂双环化合物作为热休克蛋白 90（HSP90）抑制剂的实用性。还描述了合成和使用此类化合物的方法。
• NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS
  申请人：Conforma Therapeutic Corporation

  公开号：EP1670802A2

  公开（公告）日：2006-06-21
• [EN] NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS<br/>[FR] NOUVEAUX COMPOSES HETEROCYCLIQUES UTILISES EN TANT QU'INHIBITEURS DE LA PROTEINE HSP90
  申请人：CONFORMA THERAPEUTICS CORP

  公开号：WO2005028434A2

  公开（公告）日：2005-03-31

  Novel heterocyclic compounds are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agent. Method of synthesis and use of such compounds are also described.