5,6,7,8-tetrabromo-2,3-dihydrophthalazine-1,4-dione | 1133866-08-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5,6,7,8-tetrabromo-2,3-dihydrophthalazine-1,4-dione
• CAS: 1133866-08-6
• 化学式: C₈H₂Br₄N₂O₂
• 分子量: 477.732
• InChiKey: KQFOVSHRRQBKKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  四溴苯酐 在 一水合肼 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 生成 5,6,7,8-tetrabromo-2,3-dihydrophthalazine-1,4-dione
  参考文献：
  名称：

  Synthesis of new analogs of benzotriazole, benzimidazole and phthalimide—potential inhibitors of human protein kinase CK2

  摘要：

  New derivatives of 4,5,6,7-tetrabromo-1H-1,2,3-benzotriazole (TBBt), 4,5,6,7-tetrabromo-1H-benzimidazole (TBBi), and N-substituted tetrabromophthalimides were synthesized and their effect on the activity of human protein kinase CK2 was examined. The most active were derivatives with N-hydroxypropyl substituents (IC50 in 0.32-0.54 mu M range) whereas derivatives of phthalimide were almost ineffective. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.12.071

文献信息

• Synthesis of new analogs of benzotriazole, benzimidazole and phthalimide—potential inhibitors of human protein kinase CK2
  作者：Andzelika Najda-Bernatowicz、Maja Łebska、Andrzej Orzeszko、Katarzyna Kopańska、Ewa Krzywińska、Grażyna Muszyńska、Maria Bretner

  DOI：10.1016/j.bmc.2008.12.071

  日期：2009.2

  New derivatives of 4,5,6,7-tetrabromo-1H-1,2,3-benzotriazole (TBBt), 4,5,6,7-tetrabromo-1H-benzimidazole (TBBi), and N-substituted tetrabromophthalimides were synthesized and their effect on the activity of human protein kinase CK2 was examined. The most active were derivatives with N-hydroxypropyl substituents (IC50 in 0.32-0.54 mu M range) whereas derivatives of phthalimide were almost ineffective. (c) 2009 Elsevier Ltd. All rights reserved.