2-{4-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]pyrimidin-2-ylamino}ethanol | 1454695-54-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-{4-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]pyrimidin-2-ylamino}ethanol
• 英文别名: 2-[[4-[4-(7-Chloroquinolin-4-yl)piperazin-1-yl]pyrimidin-2-yl]amino]ethanol；2-[[4-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]pyrimidin-2-yl]amino]ethanol
• CAS: 1454695-54-5
• 化学式: C₁₉H₂₁ClN₆O
• 分子量: 384.868
• InChiKey: VYVOOYYZLFUFRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  77.4
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  7-氯-4-(1-哌嗪基)喹啉 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 生成 2-{4-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]pyrimidin-2-ylamino}ethanol
  参考文献：
  名称：

  Synthesis of piperazine tethered 4-aminoquinoline-pyrimidine hybrids as potent antimalarial agents

  摘要：

  Piperazine连接的4-氨基喹啉-嘧啶杂合物被合成并针对疟原虫的W2和D6菌株进行体外抗疟活性评价。

  DOI：

  10.1039/c4ra02276a

文献信息

• AMINOQUINOLINE DERIVATIVES AND USES THEREOF
  申请人：THE MCLEAN HOSPITAL CORPORATION

  公开号：US20150023930A1

  公开（公告）日：2015-01-22

  Described herein are aminoquinoline and aminoacridine based hybrids, pharmaceutical compositions and medicaments that include such aminoquinoline and aminoacridine based hybrids, and methods of using such compounds for diagnosing and/or treating infections, neurodegerative diseases or disorders, inflammation, inflammation associated diseases and disorders, and/or diseases or disorders that are treatable with dopamine agonists such as the restless leg syndrome.

  本文描述了基于氨基喹啉和氨基蒽醌的混合物，包括含有这种基于氨基喹啉和氨基蒽醌的混合物的制药组合物和药物，以及使用这种化合物诊断和/或治疗感染、神经退行性疾病或障碍、炎症、与炎症相关的疾病和障碍以及可用多巴胺激动剂治疗的疾病或障碍（如不宁腿综合征）的方法。
• Aminoquinoline derivatives and uses thereof
  申请人：UNIVERSITY OF DELHI

  公开号：US11026943B2

  公开（公告）日：2021-06-08

  Described herein are aminoquinoline and aminoacridine based hybrids, pharmaceutical compositions and medicaments that include such aminoquinoline and aminoacridine based hybrids, and methods of using such compounds for diagnosing and/or treating infections, neurodegenerative diseases or disorders, inflammation, inflammation associated diseases and disorders, and/or diseases or disorders that are treatable with dopamine agonists such as the restless leg syndrome.

  本文描述了基于氨基喹啉和氨基吖啶的混合物、包括这种基于氨基喹啉和氨基吖啶的混合物的药物组合物和药物，以及使用这种化合物诊断和/或治疗感染、神经退行性疾病或紊乱、炎症、炎症相关疾病和紊乱和/或可使用多巴胺激动剂治疗的疾病或紊乱（如不安腿综合征）的方法。
• Aminoquinoline Derivatives and Uses Thereof
  申请人：The McLean Hospital Corporation

  公开号：US20220008418A1

  公开（公告）日：2022-01-13

  Described herein are aminoquinoline and aminoacridine based hybrids, pharmaceutical compositions and medicaments that include such aminoquinoline and aminoacridine based hybrids, and methods of using such compounds for diagnosing and/or treating infections, neurodegerative diseases or disorders, inflammation, inflammation associated diseases and disorders, and/or diseases or disorders that are treatable with dopamine agonists such as the restless leg syndrome.
• US9567316B2
  申请人：——

  公开号：US9567316B2

  公开（公告）日：2017-02-14
• Synthesis of piperazine tethered 4-aminoquinoline-pyrimidine hybrids as potent antimalarial agents
  作者：Anuj Thakur、Shabana I. Khan、Diwan S. Rawat

  DOI：10.1039/c4ra02276a

  日期：——

  Piperazine linked 4-aminoquinoline-pyrimidine hybrids were synthesized and evaluated for in vitro antimalarial activity against W2 and D6 strains of plasmodium falciparum.

  Piperazine连接的4-氨基喹啉-嘧啶杂合物被合成并针对疟原虫的W2和D6菌株进行体外抗疟活性评价。